Advanced technologies for studying circulating tumor cells at the protein level

Charles Ming Lok Chan, Thomas Chi Chuen Au, Anthony Tak Cheung Chan, Brigette Buig Yue Ma, Nancy Bo Yin Tsui, Simon Siu Man Ng, Edwin Pun Hui, Wing Chi Chan, Wing Shan Ho, Yat Ming Yung, Sze Chuen Cesar Wong

Research output: Journal article publicationReview articleAcademic researchpeer-review

3 Citations (Scopus)

Abstract

Metastasis is the main cause of cancer death. As the tumor progresses, cells from the primary tumor site are shed into the bloodstream as circulating tumor cells (CTCs). Eventually, these cells colonize other organs and form distant metastases. It is therefore imperative that we gain a better understanding of the biological characteristics of CTCs for development of novel treatment modalities to minimize metastasis-associated cancer deaths. In recent years, rapid developments in technologies for the study of CTCs have taken place. We now have a variety of tools for the isolation and examination of CTCs which were not available before. This review introduces some commonly used protein markers in CTC investigations and summarizes a few advanced technologies which have been successfully applied for studying CTC biology at the protein level.
Original languageEnglish
Pages (from-to)579-589
Number of pages11
JournalExpert Review of Proteomics
Volume10
Issue number6
DOIs
Publication statusPublished - 25 Nov 2013

Keywords

  • Cellsearch
  • Circulating tumor cells
  • CTC-chip
  • EPISPOT
  • Immunomagnetic bead
  • Proteomic

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this