Adoptive Immunotherapy: A Human Pluripotent Stem Cell Perspective

Gyuhyung Jin, Yun Chang, Jackson Duke Harris, Xiaoping Bao

Research output: Journal article publicationReview articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

The past decade has witnessed significant advances in cancer immunotherapy, particularly through the adoptive transfer of engineered T cells in treating advanced leukemias and lymphomas. Despite these excitements, challenges remain with scale, cost, and ensuring quality control of engineered immune cells, including chimeric antigen receptor T, natural killer cells, and macrophages. The advent of human pluripotent stem cells (hPSCs), including human embryonic stem cells and induced pluripotent stem cells, has transformed immunotherapy by providing a scalable, off-The-shelf source of any desired immune cells for basic research, translational studies, and clinical interventions. The tractability of hPSCs for gene editing could also generate homogenous, universal cellular products with custom functionality for individual or combinatory therapeutic applications. This review will explore various immune cell types whose directed differentiation from hPSCs has been achieved and recently adapted for translational immunotherapy and feature forward-looking bioengineering techniques shaping the future of the stem cell field.

Original languageEnglish
Pages (from-to)439-467
Number of pages29
JournalCells Tissues Organs
Volume212
Issue number5
DOIs
Publication statusPublished - 1 Dec 2023
Externally publishedYes

Keywords

  • Bioengineering
  • Human pluripotent stem cells
  • Immunoengineering
  • Immunotherapy

ASJC Scopus subject areas

  • Anatomy
  • Histology

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