Acoustic characterization of nano gas vesicles

Yaoheng Yang; Zhihai Qiu; Cheng Liu; Yongming Huang; Lei Sun; Jiyan Dai

doi:10.1109/ULTSYM.2015.0386

Acoustic characterization of nano gas vesicles

Yaoheng Yang, Zhihai Qiu, Cheng Liu, Yongming Huang, Lei Sun, Jiyan Dai

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

2 Citations (Scopus)

Abstract

Due to the lack of a proper contrast agent, the scope of molecular ultrasound imaging is restricted within blood vessels. Recently reported biogenic nano gas vesicle (NGV), 400nm by 100nm rod shape nano-bubbles encapsulated by a bilayer protein shell, may extend molecular ultrasound imaging capability and find substantial values in therapy. In this study, we investigated the fundamental acoustic characteristics, including attenuation and non-linear property of NGV. Resonance frequency was obtained by measuring the attenuation coefficient of NGV using pulse-echo system and found to be at high frequency region greater than 80MHz. By testing the non-linear property of NGV, it shows significant second harmonic frequency when sonicated by 40MHz ultrasound signal. The stability is well enhanced without significant broken for more than 6 hrs. With the advantage of nanometer size, good ultrasonic contrast and enhanced stability, it is believed to perform extravascular molecular imaging with ultrasound modality.

Original language	English
Title of host publication	2015 IEEE International Ultrasonics Symposium, IUS 2015
Publisher	IEEE
ISBN (Electronic)	9781479981823
DOIs	https://doi.org/10.1109/ULTSYM.2015.0386
Publication status	Published - 13 Nov 2015
Event	IEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan Duration: 21 Oct 2015 → 24 Oct 2015

Conference

Conference	IEEE International Ultrasonics Symposium, IUS 2015
Country/Territory	Taiwan
City	Taipei
Period	21/10/15 → 24/10/15

Keywords

acoustic characterization
molecular imaging
Nano gas vesicle
nanobubble
ultrasound contrast agent

ASJC Scopus subject areas

Acoustics and Ultrasonics

More information

10.1109/ULTSYM.2015.0386

Cite this

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title = "Acoustic characterization of nano gas vesicles",

abstract = "Due to the lack of a proper contrast agent, the scope of molecular ultrasound imaging is restricted within blood vessels. Recently reported biogenic nano gas vesicle (NGV), 400nm by 100nm rod shape nano-bubbles encapsulated by a bilayer protein shell, may extend molecular ultrasound imaging capability and find substantial values in therapy. In this study, we investigated the fundamental acoustic characteristics, including attenuation and non-linear property of NGV. Resonance frequency was obtained by measuring the attenuation coefficient of NGV using pulse-echo system and found to be at high frequency region greater than 80MHz. By testing the non-linear property of NGV, it shows significant second harmonic frequency when sonicated by 40MHz ultrasound signal. The stability is well enhanced without significant broken for more than 6 hrs. With the advantage of nanometer size, good ultrasonic contrast and enhanced stability, it is believed to perform extravascular molecular imaging with ultrasound modality.",

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AU - Yang, Yaoheng

AU - Qiu, Zhihai

AU - Liu, Cheng

AU - Huang, Yongming

AU - Sun, Lei

AU - Dai, Jiyan

PY - 2015/11/13

Y1 - 2015/11/13

N2 - Due to the lack of a proper contrast agent, the scope of molecular ultrasound imaging is restricted within blood vessels. Recently reported biogenic nano gas vesicle (NGV), 400nm by 100nm rod shape nano-bubbles encapsulated by a bilayer protein shell, may extend molecular ultrasound imaging capability and find substantial values in therapy. In this study, we investigated the fundamental acoustic characteristics, including attenuation and non-linear property of NGV. Resonance frequency was obtained by measuring the attenuation coefficient of NGV using pulse-echo system and found to be at high frequency region greater than 80MHz. By testing the non-linear property of NGV, it shows significant second harmonic frequency when sonicated by 40MHz ultrasound signal. The stability is well enhanced without significant broken for more than 6 hrs. With the advantage of nanometer size, good ultrasonic contrast and enhanced stability, it is believed to perform extravascular molecular imaging with ultrasound modality.

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KW - acoustic characterization

KW - molecular imaging

KW - Nano gas vesicle

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KW - ultrasound contrast agent

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M3 - Conference article published in proceeding or book

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Acoustic characterization of nano gas vesicles

Abstract

Conference

Keywords

ASJC Scopus subject areas

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