Acoustic characterization of nano gas vesicles

Yaoheng Yang, Zhihai Qiu, Cheng Liu, Yongming Huang, Lei Sun, Jiyan Dai

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

2 Citations (Scopus)


Due to the lack of a proper contrast agent, the scope of molecular ultrasound imaging is restricted within blood vessels. Recently reported biogenic nano gas vesicle (NGV), 400nm by 100nm rod shape nano-bubbles encapsulated by a bilayer protein shell, may extend molecular ultrasound imaging capability and find substantial values in therapy. In this study, we investigated the fundamental acoustic characteristics, including attenuation and non-linear property of NGV. Resonance frequency was obtained by measuring the attenuation coefficient of NGV using pulse-echo system and found to be at high frequency region greater than 80MHz. By testing the non-linear property of NGV, it shows significant second harmonic frequency when sonicated by 40MHz ultrasound signal. The stability is well enhanced without significant broken for more than 6 hrs. With the advantage of nanometer size, good ultrasonic contrast and enhanced stability, it is believed to perform extravascular molecular imaging with ultrasound modality.
Original languageEnglish
Title of host publication2015 IEEE International Ultrasonics Symposium, IUS 2015
ISBN (Electronic)9781479981823
Publication statusPublished - 13 Nov 2015
EventIEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan
Duration: 21 Oct 201524 Oct 2015


ConferenceIEEE International Ultrasonics Symposium, IUS 2015


  • acoustic characterization
  • molecular imaging
  • Nano gas vesicle
  • nanobubble
  • ultrasound contrast agent

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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