Acid-promoted DNA-cleaving activities and total synthesis of varacin C

Alex H.F. Lee; Jian Chen; Dongsheng Liu; Yun Chung Leung; Albert S.C. Chan; Tianhu Li

doi:10.1021/ja020531i

Acid-promoted DNA-cleaving activities and total synthesis of varacin C

Alex H.F. Lee
, Jian Chen
, Dongsheng Liu
, Yun Chung Leung
, Albert S.C. Chan
, Tianhu Li

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

43 Citations (Scopus)

Abstract

The first total synthesis of the antibiotic varacin C has been accomplished. In addition, it has been demonstrated that this antibiotic exhibits potent antitumor activity and is capable of causing efficient DNA cleavage under acidic conditions.

Original language	English
Pages (from-to)	13972-13973
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	124
Issue number	47
DOIs	https://doi.org/10.1021/ja020531i
Publication status	Published - 27 Nov 2002

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja020531i

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title = "Acid-promoted DNA-cleaving activities and total synthesis of varacin C",

abstract = "The first total synthesis of the antibiotic varacin C has been accomplished. In addition, it has been demonstrated that this antibiotic exhibits potent antitumor activity and is capable of causing efficient DNA cleavage under acidic conditions.",

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year = "2002",

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AU - Lee, Alex H.F.

AU - Chen, Jian

AU - Liu, Dongsheng

AU - Leung, Yun Chung

AU - Chan, Albert S.C.

AU - Li, Tianhu

PY - 2002/11/27

Y1 - 2002/11/27

N2 - The first total synthesis of the antibiotic varacin C has been accomplished. In addition, it has been demonstrated that this antibiotic exhibits potent antitumor activity and is capable of causing efficient DNA cleavage under acidic conditions.

AB - The first total synthesis of the antibiotic varacin C has been accomplished. In addition, it has been demonstrated that this antibiotic exhibits potent antitumor activity and is capable of causing efficient DNA cleavage under acidic conditions.

UR - https://www.scopus.com/pages/publications/0037184404

U2 - 10.1021/ja020531i

DO - 10.1021/ja020531i

M3 - Journal article

SN - 0002-7863

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 47

ER -

Acid-promoted DNA-cleaving activities and total synthesis of varacin C

Abstract

ASJC Scopus subject areas

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