Acid-promoted DNA-cleaving activities and total synthesis of varacin C

Alex H.F. Lee, Jian Chen, Dongsheng Liu, Yun Chung Leung, Albert S.C. Chan, Tianhu Li

Research output: Journal article publicationJournal articleAcademic researchpeer-review

40 Citations (Scopus)

Abstract

The first total synthesis of the antibiotic varacin C has been accomplished. In addition, it has been demonstrated that this antibiotic exhibits potent antitumor activity and is capable of causing efficient DNA cleavage under acidic conditions.
Original languageEnglish
Pages (from-to)13972-13973
Number of pages2
JournalJournal of the American Chemical Society
Volume124
Issue number47
DOIs
Publication statusPublished - 27 Nov 2002

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry

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