A Versatile Dynamic Mussel-Inspired Biointerface: From Specific Cell Behavior Modulation to Selective Cell Isolation

Lei Liu, Xiaohua Tian, Yue Ma, Yuqing Duan, Xin Zhao, Guoqing Pan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

51 Citations (Scopus)

Abstract

Reported here is a novel dynamic biointerface based on reversible catechol-boronate chemistry. Biomimetically designed peptides with a catechol-containing sequence and a cell-binding sequence at each end were initially obtained. The mussel-inspired peptides were then reversibly bound to a phenylboronic acid (PBA) containing polymer-grafted substrate through sugar-responsive catechol-boronate interactions. The resultant biointerface is thus capable of dynamic presentation of the bioactivity (i.e. the cell-binding sequence) by virtue of changing sugar concentrations in the system (similar to human glycemic volatility). In addition, the sugar-responsive biointerface enables not only dynamic modulation of stem cell adhesion behaviors but also selective isolation of tumor cells. Considering the highly biomimetic nature and biological stimuli-responsiveness, this mussel-inspired dynamic biointerface holds great promise in both fundamental cell biology research and advanced medical applications.

Original languageEnglish
Pages (from-to)7878-7882
Number of pages5
JournalAngewandte Chemie - International Edition
Volume57
Issue number26
DOIs
Publication statusPublished - 25 Jun 2018

Keywords

  • cell adhesion
  • dynamic biointerface
  • mussel-inspired peptides
  • reversible covalent bonds
  • tumor cell capture

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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