A universal biocompatible coating for enhanced lubrication and bacterial inhibition

Di Suo, Jingdong Rao, Haimang Wang, Ziheng Zhang, Hang Mei Polly Leung, Hongyu Zhang, Xiaoming Tao, Xin Zhao (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

5 Citations (Scopus)

Abstract

Antibacterial coatings that inhibit bacterial adhesion are essential for many implanted medical devices. A variety of antibacterial strategies, such as repelling or killing bacteria, have been developed, but not yet been completely successful. Here, we develop a universal biocompatible coating for enhanced lubrication and bacterial inhibition. The coating is designed based on mussel-inspired surface-attachable dopamine bases and consists of lubricating zwitterionic polymers poly(2-methacryloxyethyl phosphorylcholine) (MPC) and a bacterial membrane destroying anti-bacteria molecule poly(3-hydroxybutyric acid) (PHB). The coating boasts strong adhesion to surfaces of various materials (such as polydimethylsiloxane (PDMS)/ceramic/316L stainless steel (316L SS); it is biocompatible, and cell/platelet/bacteria repelling, significantly inhibiting bacterial growth. We envision that our strategy represents a universal strategy for surface functionalization of a variety of biomedical devices and implants.
Original languageEnglish
Pages (from-to)3493-3502
Number of pages10
JournalBiomaterials Science
Volume10
Issue number13
DOIs
Publication statusPublished - 9 May 2022

Keywords

  • biomimetic coating
  • lubrication
  • bacterial resistance
  • hemocompatibility
  • surface functionalization

ASJC Scopus subject areas

  • Biomedical Engineering
  • General Materials Science

Fingerprint

Dive into the research topics of 'A universal biocompatible coating for enhanced lubrication and bacterial inhibition'. Together they form a unique fingerprint.

Cite this