A universal biocompatible coating for enhanced lubrication and bacterial inhibition

Di Suo; Jingdong Rao; Haimang Wang; Ziheng Zhang; Hang Mei Polly Leung; Hongyu Zhang; Xiaoming Tao; Xin Zhao

doi:10.1039/D2BM00598K

A universal biocompatible coating for enhanced lubrication and bacterial inhibition

Di Suo, Jingdong Rao, Haimang Wang, Ziheng Zhang, Hang Mei Polly Leung, Hongyu Zhang, Xiaoming Tao, Xin Zhao (Corresponding Author)

Research output: Journal article publication › Journal article › Academic research › peer-review

10 Citations (Scopus)

Abstract

Antibacterial coatings that inhibit bacterial adhesion are essential for many implanted medical devices. A variety of antibacterial strategies, such as repelling or killing bacteria, have been developed, but not yet been completely successful. Here, we develop a universal biocompatible coating for enhanced lubrication and bacterial inhibition. The coating is designed based on mussel-inspired surface-attachable dopamine bases and consists of lubricating zwitterionic polymers poly(2-methacryloxyethyl phosphorylcholine) (MPC) and a bacterial membrane destroying anti-bacteria molecule poly(3-hydroxybutyric acid) (PHB). The coating boasts strong adhesion to surfaces of various materials (such as polydimethylsiloxane (PDMS)/ceramic/316L stainless steel (316L SS); it is biocompatible, and cell/platelet/bacteria repelling, significantly inhibiting bacterial growth. We envision that our strategy represents a universal strategy for surface functionalization of a variety of biomedical devices and implants.

Original language	English
Pages (from-to)	3493-3502
Number of pages	10
Journal	Biomaterials Science
Volume	10
Issue number	13
DOIs	https://doi.org/10.1039/D2BM00598K
Publication status	Published - 9 May 2022

Keywords

biomimetic coating
lubrication
bacterial resistance
hemocompatibility
surface functionalization

ASJC Scopus subject areas

Biomedical Engineering
General Materials Science

More information

10.1039/D2BM00598K

http://hdl.handle.net/10397/95774

Cite this

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title = "A universal biocompatible coating for enhanced lubrication and bacterial inhibition",

abstract = "Antibacterial coatings that inhibit bacterial adhesion are essential for many implanted medical devices. A variety of antibacterial strategies, such as repelling or killing bacteria, have been developed, but not yet been completely successful. Here, we develop a universal biocompatible coating for enhanced lubrication and bacterial inhibition. The coating is designed based on mussel-inspired surface-attachable dopamine bases and consists of lubricating zwitterionic polymers poly(2-methacryloxyethyl phosphorylcholine) (MPC) and a bacterial membrane destroying anti-bacteria molecule poly(3-hydroxybutyric acid) (PHB). The coating boasts strong adhesion to surfaces of various materials (such as polydimethylsiloxane (PDMS)/ceramic/316L stainless steel (316L SS); it is biocompatible, and cell/platelet/bacteria repelling, significantly inhibiting bacterial growth. We envision that our strategy represents a universal strategy for surface functionalization of a variety of biomedical devices and implants.",

keywords = "biomimetic coating, lubrication, bacterial resistance, hemocompatibility, surface functionalization",

author = "Di Suo and Jingdong Rao and Haimang Wang and Ziheng Zhang and Leung, {Hang Mei Polly} and Hongyu Zhang and Xiaoming Tao and Xin Zhao",

note = "Funding Information: This work was supported by the General Research Fund (15202119) of the Research Grants Council of Hong Kong. Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry",

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AU - Suo, Di

AU - Rao, Jingdong

AU - Wang, Haimang

AU - Zhang, Ziheng

AU - Leung, Hang Mei Polly

AU - Zhang, Hongyu

AU - Tao, Xiaoming

AU - Zhao, Xin

PY - 2022/5/9

Y1 - 2022/5/9

N2 - Antibacterial coatings that inhibit bacterial adhesion are essential for many implanted medical devices. A variety of antibacterial strategies, such as repelling or killing bacteria, have been developed, but not yet been completely successful. Here, we develop a universal biocompatible coating for enhanced lubrication and bacterial inhibition. The coating is designed based on mussel-inspired surface-attachable dopamine bases and consists of lubricating zwitterionic polymers poly(2-methacryloxyethyl phosphorylcholine) (MPC) and a bacterial membrane destroying anti-bacteria molecule poly(3-hydroxybutyric acid) (PHB). The coating boasts strong adhesion to surfaces of various materials (such as polydimethylsiloxane (PDMS)/ceramic/316L stainless steel (316L SS); it is biocompatible, and cell/platelet/bacteria repelling, significantly inhibiting bacterial growth. We envision that our strategy represents a universal strategy for surface functionalization of a variety of biomedical devices and implants.

AB - Antibacterial coatings that inhibit bacterial adhesion are essential for many implanted medical devices. A variety of antibacterial strategies, such as repelling or killing bacteria, have been developed, but not yet been completely successful. Here, we develop a universal biocompatible coating for enhanced lubrication and bacterial inhibition. The coating is designed based on mussel-inspired surface-attachable dopamine bases and consists of lubricating zwitterionic polymers poly(2-methacryloxyethyl phosphorylcholine) (MPC) and a bacterial membrane destroying anti-bacteria molecule poly(3-hydroxybutyric acid) (PHB). The coating boasts strong adhesion to surfaces of various materials (such as polydimethylsiloxane (PDMS)/ceramic/316L stainless steel (316L SS); it is biocompatible, and cell/platelet/bacteria repelling, significantly inhibiting bacterial growth. We envision that our strategy represents a universal strategy for surface functionalization of a variety of biomedical devices and implants.

KW - biomimetic coating

KW - lubrication

KW - bacterial resistance

KW - hemocompatibility

KW - surface functionalization

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U2 - 10.1039/D2BM00598K

DO - 10.1039/D2BM00598K

M3 - Journal article

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JO - Biomaterials Science

JF - Biomaterials Science

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ER -

A universal biocompatible coating for enhanced lubrication and bacterial inhibition

Abstract

Keywords

ASJC Scopus subject areas

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