A thiazole orange derivative targeting the bacterial protein FtsZ shows potent antibacterial activity

Keyphrases

• Antibacterial Activity 100%
• Bacterial Cell Division 50%
• Bacterial Proteins 100%
• Cell-based 50%
• Chemotype 50%
• Clinically Significant 50%
• Dynamic Assembly 50%
• Escherichia Coli 50%
• FtsZ 100%
• FtsZ Polymerization 50%
• FtsZ Protein 50%
• Low Cytotoxicity 50%
• Mammalian Cells 50%
• Methicillin-resistant Staphylococcus Aureus 50%
• Multidrug Resistance 50%
• NDM-1 50%
• New Antibiotics 50%
• Novel Mechanism of Action 50%
• Ring Formation 50%
• Small Molecules 50%
• Thiazole Orange 100%
• Tubulin Polymerization 50%
• Vancomycin-resistant Enterococci 50%
• Z-ring 50%

Biochemistry, Genetics and Molecular Biology

• Antibacterial Activity 100%
• Bacterial Protein 100%
• Bactericidal Activity 25%
• Cell Division 25%
• Cytotoxicity 25%
• Escherichia coli 25%
• FtsZ 100%
• Mammalian Cell 25%
• Methicillin Resistant Staphylococcus Aureus 25%
• Microtubule Assembly 25%
• Multidrug Resistance 25%
• Prevalence 25%
• Small Molecule 25%
• Thiazole 100%
• Vancomycin Resistant Enterococcus 25%

Immunology and Microbiology

• Antibacterial Activity 100%
• Bacterial Cell 50%
• Bactericidal Activity 50%
• Cell Division 50%
• Chemotype 50%
• Cytotoxicity 50%
• Escherichia coli 50%
• Methicillin-Resistant Staphylococcus Aureus 50%
• Microtubule Assembly 50%
• Multidrug Resistance 50%
• Prevalence 50%
• Vancomycin-Resistant Enterococcus 50%