A Systematic Review and Meta-Analysis of the Effectiveness of Neuroprotectants for Paclitaxel-Induced Peripheral Neuropathy

Alisha Joan Leen, Dominic Wei Ting Yap, Chong Boon Teo, Benjamin Kye Jyn Tan, Alex Molassiotis, Hiroshi Ishiguro, Sarah Wei Xian Fan, Raghav Sundar, Yu Yang Soon, Aishwarya Bandla

Research output: Journal article publicationReview articleAcademic researchpeer-review

2 Citations (Scopus)


Background: Paclitaxel-induced peripheral neuropathy (PIPN) is a disabling side effect of paclitaxel with few effective preventive strategies. We aim to determine the efficacy of pharmacological and non-pharmacological neuroprotective interventions in preventing PIPN incidence. Methods: Biomedical literature databases were searched from years 2000 to 2021 for trials comparing neuroprotective interventions and control. Meta-analysis was performed using the random-effects model. The primary outcome was the incidence of PIPN. Results: Of 24 relevant controlled trials, 14 were eligible for meta-analysis. Pooled results from seven non-pharmacological trials were associated with a statistically significant 48% relative reduction of PIPN risk with low heterogeneity. Conversely, pooled results from six pharmacological trials were associated with a significant 20% relative reduction of PIPN risk with moderate heterogeneity. Both pharmacological and non-pharmacological approaches appear effective in reducing PIPN incidence in the treatment arm compared to control (pooled RR < 1). Conclusion: Current evidence suggests that both interventions may reduce PIPN risk. Non-pharmacological interventions appear more effective than pharmacological interventions.

Original languageEnglish
Article number763229
JournalFrontiers in Oncology
Publication statusPublished - 5 Jan 2022


  • chemotherapy-induced peripheral neuropathy (CIPN)
  • neuroprotection
  • non-invasive
  • paclitaxel-induced peripheral neuropathy
  • prevention
  • taxane

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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