A strategy for simultaneously realizing the cubic-to-hexagonal phase transition and controlling the small size of NaYF4:Yb 3+,Er3+ nanocrystals for in vitro cell imaging

Zhen Ling Wang, Jianhua Hao, Helen L W Chan, Wing Tak Wong, Ka Leung Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

83 Citations (Scopus)


Hexagonal-phase NaYF4:Yb3+,Er3+ up-conversion nanocrystals (UCNCs) are synthesized by a combination of refluxing and hydrothermal treatment. This strategy leads to only a slight increase in particle size, from 4.5 to ca. 10 nm, during the cubic-to-hexagonal phase transition. The hexagonal UCNCs can be internalized by HeLa cells and exhibit visible emission in the cells under near-infrared excitation. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)1863-1868
Number of pages6
Issue number12
Publication statusPublished - 25 Jun 2012


  • biosensors
  • fluorescent probes
  • imaging
  • lanthanide nanocrystals
  • phase transitions

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)

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