A small-sized benzothiazole-indolium fluorescent probe: The study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

Bo Xin Zheng; Meng Ting She; Wei Long; Yong Yu Xu; Yi Han Zhang; Xuan He Huang; Wenjie Liu; Jin Qiang Hou; Wing Leung Wong; Yu Jing Lu

doi:10.1039/d0cc06525k

A small-sized benzothiazole-indolium fluorescent probe: The study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

Bo Xin Zheng, Meng Ting She, Wei Long, Yong Yu Xu, Yi Han Zhang, Xuan He Huang, Wenjie Liu, Jin Qiang Hou, Wing Leung Wong (Corresponding Author), Yu Jing Lu

Research output: Journal article publication › Journal article › Academic research › peer-review

22 Citations (Scopus)

Abstract

A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell imaging and it was found to be able to inhibit the amplification of the c-MYC G-rich sequence (G-quadruplex) and down-regulate oncogene c-MYC expression in human cancer cells (HeLa). This journal is

Original language	English
Pages (from-to)	15016-15019
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	95
DOIs	https://doi.org/10.1039/d0cc06525k
Publication status	Published - 11 Dec 2020

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/d0cc06525k

http://hdl.handle.net/10397/88443

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Zheng, B. X., She, M. T., Long, W., Xu, Y. Y., Zhang, Y. H., Huang, X. H., Liu, W., Hou, J. Q., Wong, W. L., & Lu, Y. J. (2020). A small-sized benzothiazole-indolium fluorescent probe: The study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging. Chemical Communications, 56(95), 15016-15019. https://doi.org/10.1039/d0cc06525k

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doi = "10.1039/d0cc06525k",

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A small-sized benzothiazole-indolium fluorescent probe: The study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging. / Zheng, Bo Xin; She, Meng Ting; Long, Wei et al.
In: Chemical Communications, Vol. 56, No. 95, 11.12.2020, p. 15016-15019.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

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AU - Zheng, Bo Xin

AU - She, Meng Ting

AU - Long, Wei

AU - Xu, Yong Yu

AU - Zhang, Yi Han

AU - Huang, Xuan He

AU - Liu, Wenjie

AU - Hou, Jin Qiang

AU - Wong, Wing Leung

AU - Lu, Yu Jing

PY - 2020/12/11

Y1 - 2020/12/11

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AB - A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell imaging and it was found to be able to inhibit the amplification of the c-MYC G-rich sequence (G-quadruplex) and down-regulate oncogene c-MYC expression in human cancer cells (HeLa). This journal is

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DO - 10.1039/d0cc06525k

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A small-sized benzothiazole-indolium fluorescent probe: The study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

Abstract

ASJC Scopus subject areas

UN SDGs

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