A small-sized benzothiazole-indolium fluorescent probe: The study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

Bo Xin Zheng; Meng Ting She; Wei Long; Yong Yu Xu; Yi Han Zhang; Xuan He Huang; Wenjie Liu; Jin Qiang Hou; Wing Leung Wong; Yu Jing Lu

doi:10.1039/d0cc06525k

A small-sized benzothiazole-indolium fluorescent probe: The study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

Bo Xin Zheng
, Meng Ting She
, Wei Long
, Yong Yu Xu
, Yi Han Zhang
, Xuan He Huang
, Wenjie Liu
, Jin Qiang Hou
, Wing Leung Wong (Corresponding Author)
, Yu Jing Lu

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

23 Citations (Scopus)

Abstract

A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell imaging and it was found to be able to inhibit the amplification of the c-MYC G-rich sequence (G-quadruplex) and down-regulate oncogene c-MYC expression in human cancer cells (HeLa). This journal is

Original language	English
Pages (from-to)	15016-15019
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	95
DOIs	https://doi.org/10.1039/d0cc06525k
Publication status	Published - 11 Dec 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

More information

10.1039/d0cc06525k

http://hdl.handle.net/10397/88443

Cite this

Zheng, B. X., She, M. T., Long, W., Xu, Y. Y., Zhang, Y. H., Huang, X. H., Liu, W., Hou, J. Q., Wong, W. L., & Lu, Y. J. (2020). A small-sized benzothiazole-indolium fluorescent probe: The study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging. Chemical Communications, 56(95), 15016-15019. https://doi.org/10.1039/d0cc06525k

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month = dec,

day = "11",

doi = "10.1039/d0cc06525k",

language = "English",

volume = "56",

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publisher = "Royal Society of Chemistry",

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A small-sized benzothiazole-indolium fluorescent probe: The study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging. / Zheng, Bo Xin; She, Meng Ting; Long, Wei et al.
In: Chemical Communications, Vol. 56, No. 95, 11.12.2020, p. 15016-15019.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

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AU - Zheng, Bo Xin

AU - She, Meng Ting

AU - Long, Wei

AU - Xu, Yong Yu

AU - Zhang, Yi Han

AU - Huang, Xuan He

AU - Liu, Wenjie

AU - Hou, Jin Qiang

AU - Wong, Wing Leung

AU - Lu, Yu Jing

PY - 2020/12/11

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A small-sized benzothiazole-indolium fluorescent probe: The study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

Abstract

UN SDGs

ASJC Scopus subject areas

More information

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