A small-sized benzothiazole-indolium fluorescent probe: The study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

Bo Xin Zheng, Meng Ting She, Wei Long, Yong Yu Xu, Yi Han Zhang, Xuan He Huang, Wenjie Liu, Jin Qiang Hou, Wing Leung Wong (Corresponding Author), Yu Jing Lu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

4 Citations (Scopus)

Abstract

A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell imaging and it was found to be able to inhibit the amplification of the c-MYC G-rich sequence (G-quadruplex) and down-regulate oncogene c-MYC expression in human cancer cells (HeLa). This journal is

Original languageEnglish
Pages (from-to)15016-15019
Number of pages4
JournalChemical Communications
Volume56
Issue number95
DOIs
Publication statusPublished - 11 Dec 2020

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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