Abstract
A convenient synthetic route to 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (cyclen) (1) with high yield and excellent regioselectivity is described. Compound 1 reacted with a range of functionalized alkyl halides under two reaction conditions to give mono-N-alkylated 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (2-9) in good yield.
| Original language | English |
|---|---|
| Pages (from-to) | 2956-2959 |
| Number of pages | 4 |
| Journal | Journal of Organic Chemistry |
| Volume | 68 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 4 Apr 2003 |
| Externally published | Yes |
ASJC Scopus subject areas
- Organic Chemistry
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