A simple, regioselective synthesis of 1,4-bis(tert-butoxycarbonylmethyl)-tetraazacyclododecane

Cong Li, Wing Tak Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

46 Citations (Scopus)


A convenient synthetic route to 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (cyclen) (1) with high yield and excellent regioselectivity is described. Compound 1 reacted with a range of functionalized alkyl halides under two reaction conditions to give mono-N-alkylated 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (2-9) in good yield.
Original languageEnglish
Pages (from-to)2956-2959
Number of pages4
JournalJournal of Organic Chemistry
Issue number7
Publication statusPublished - 4 Apr 2003
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry


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