A sensing platform for hypoxanthine detection based on amino-functionalized metal organic framework nanosheet with peroxidase mimic and fluorescence properties

Shuisheng Hu, Jingjing Yan, Xueming Huang, Longhua Guo, Zhenyu Lin, Fang Luo, Bin Qiu, Kwok Yin Wong, Guonan Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

33 Citations (Scopus)


The amino-functionalized metal organic framework (NH 2-Cu-MOF) was fabricated via bottom-up synthesis strategy. Detailed characterization using electron microscopy, X-ray photoelectron spectroscopy and atomic force microscopy demonstrated that the as-synthesized NH 2-Cu-MOF was two-dimensional nanosheet (a thin thickness ∼4.2 nm). Results showed that the as-synthesized NH 2-Cu-MOF nanosheet possessed fluorescence property (λ em = 425 nm) as well as peroxidase mimic activity. On the basis of these two properties, we proposed a biosensor for hypoxanthine detection. The fluorescence intensity had a linear relationship with the hypoxanthine concentration in the range of 10–2000 μM. The limit of detection was 3.93 μM (S/N = 3). This work contributes to the synthesis of a new two-dimensional MOF nanosheet and extends the application of two-dimensional MOF nanosheet on biological luminescent sensors.

Original languageEnglish
Pages (from-to)312-319
Number of pages8
JournalSensors and Actuators, B: Chemical
Publication statusPublished - 15 Aug 2018


  • Biosensor
  • Bottom-up synthesis
  • Hypoxanthine
  • Peroxidase mimic
  • Two-dimensional metal organic framework nanosheet

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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