Abstract
The amino-functionalized metal organic framework (NH 2-Cu-MOF) was fabricated via bottom-up synthesis strategy. Detailed characterization using electron microscopy, X-ray photoelectron spectroscopy and atomic force microscopy demonstrated that the as-synthesized NH 2-Cu-MOF was two-dimensional nanosheet (a thin thickness ∼4.2 nm). Results showed that the as-synthesized NH 2-Cu-MOF nanosheet possessed fluorescence property (λ em = 425 nm) as well as peroxidase mimic activity. On the basis of these two properties, we proposed a biosensor for hypoxanthine detection. The fluorescence intensity had a linear relationship with the hypoxanthine concentration in the range of 10–2000 μM. The limit of detection was 3.93 μM (S/N = 3). This work contributes to the synthesis of a new two-dimensional MOF nanosheet and extends the application of two-dimensional MOF nanosheet on biological luminescent sensors.
Original language | English |
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Pages (from-to) | 312-319 |
Number of pages | 8 |
Journal | Sensors and Actuators, B: Chemical |
Volume | 267 |
DOIs | |
Publication status | Published - 15 Aug 2018 |
Keywords
- Biosensor
- Bottom-up synthesis
- Hypoxanthine
- Peroxidase mimic
- Two-dimensional metal organic framework nanosheet
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Instrumentation
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Metals and Alloys
- Electrical and Electronic Engineering
- Materials Chemistry