A Review on the Sources, Structures, and Pharmacological Activities of Lucidenic Acids

Chengwen Zheng, Panthakarn Rangsinth, Polly H.T. Shiu, Wen Wang, Renkai Li, Jingjing Li, Yiu Wa Kwan, George P.H. Leung (Corresponding Author)

Research output: Journal article publicationReview articleAcademic researchpeer-review

10 Citations (Scopus)


Ganoderma lucidum has long been used as a multi-purpose plant and functional food. The pharmacological properties of G. lucidum are primarily attributed to its polysaccharides and triterpenoids. Ganoderic and lucidenic acids are the two major triterpenoids groups in G. lucidum. Despite the discovery of 22 types of lucidenic acids, research on lucidenic acids is significantly less extensive compared to that on ganoderic acid. To the best of our knowledge, for the first time, in this review, we aimed to summarize the sources, contents, chemical structures, and pharmacological effects, including anti-cancer, anti-inflammatory, antioxidant, anti-viral, neuroprotective, anti-hyperlipidemic, anti-hypercholesterolemic, and anti-diabetic properties, of lucidenic acids. Studies on lucidenic acids are still preliminary and have several limitations. Therefore, more in-depth studies with optimal designs are essential for the development of lucidenic acids as medicines, functional foods, and nutraceuticals.

Original languageEnglish
Article number1756
Issue number4
Publication statusPublished - 12 Feb 2023


  • Ganoderma lucidum
  • lucidenic acids
  • pharmacological effects

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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