A relook into the association of the estrogen receptor α gene (PvuII, XbaI) and adolescent idiopathic scoliosis: A study of 540 Chinese cases

Nelson Leung Sang Tang, Hiu Yan Yeung, Kwong Man Lee, Vivian Wing Yin Hung, Catherine Siu King Cheung, Bobby Kin Wah Ng, Rachel Kwok, Xia Guo, Ling Qin, Jack Chun Yiu Cheng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

58 Citations (Scopus)


STUDY DESIGN. A genetic association study of estrogen receptor-α gene (ESR1) with adolescent idiopathic scoliosis (AIS) in Chinese. OBJECTIVES. To investigate whether: 1) PvuII and XbaI polymorphisms in ESR1 are predisposition factor for AIS and 2) these polymorphisms correlate with the severity of curvature in AIS. SUMMARY OF BACKGROUND DATA. A common single nucleotide polymorphism (SNP) in ESR1 (XbaI) was found to be associated with curve severity in Japanese AIS patients recently. The role of ESR1 as a predisposition gene using a case-control design in other ethnic groups is required to confirm the previous associations. METHODS. A total of 540 Chinese AIS girls with Cobb angle above 20° were recruited as cases together with 260 healthy controls. The effect of ESR1 SNPs on severity of scoliosis was analyzed in a subgroup of AIS patients (n = 364) followed up until skeletal maturity with the maximum Cobb angle recorded. Two SNPs in ESR1 were genotyped by PCR-restriction fragment length polymorphism in all subjects. RESULTS. The allelic frequency of X allele was 23% in both case and control groups. The P allele was found at allelic frequency of 40% and 36% in the case and control groups, respectively. No association between the two ESR1 SNPs and the occurrence of AIS by both genotype and haplotype analysis could be established, suggesting that both SNPs were not predisposition alleles for AIS. AIS patients with different genotypes showed no difference in the maximum Cobb angle. No association was found between the genotype and anthropometric measurements in AIS patients. CONCLUSION. The previously reported association with curve severity could not be replicated in our large series of Chinese AIS patients. The current study also did not show any association of the 2 SNPs with increased risk of having AIS.
Original languageEnglish
Pages (from-to)2463-2468
Number of pages6
Issue number21
Publication statusPublished - 1 Oct 2006


  • Adolescent idiopathic scoliosis
  • Anthropometry
  • Curve severity
  • Estrogen receptor
  • Restriction fragment length polymorphism

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology


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