A reconfigurable and portable acoustofluidic system based on flexible printed circuit board for the manipulation of microspheres

Roman Mikhaylov, Mercedes Stringer Martin, Povilas Dumcius, Hanlin Wang, Fangda Wu, Xiaoyan Zhang, Victory Akhimien, Chao Sun, Aled Clayton, Yongqing Fu, Lin Ye, Zhiqiang Dong, Zhenlin Wu, Xin Yang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

Acoustofluidic devices based on surface acoustic waves (SAWs) have been widely applied in biomedical research for the manipulation and separation of cells. In this work, we develop an accessible manufacturing process to fabricate an acoustofluidic device consisting of a SAW interdigital transducer (IDT) and a polydimethylsiloxane microchannel. The IDT is manufactured using a flexible printed circuit board pre-patterned with interdigital electrodes that is mechanically coupled with a piezoelectric substrate. A new microchannel moulding technique is realised by 3D printing on glass slides and is demonstrated by constructing the microchannel for the acoustofluidic device. The flexible clamping mechanism, used to construct the device, allows the reconfigurable binding between the IDT and the microchannel. This unique construction makes the acoustofluidic device capable of adjusting the angle between the microchannel and the SAW propagation, without refabrication, via either rotating the IDT or the microchannel. The angle adjustment is demonstrated by setting the polystyrene microsphere aggregation angle to -5 , 0 , 6 , and 15 . Acoustic energy density measurements demonstrate the velocity of microsphere aggregation in the device can be accurately controlled by the input power. The manufacturing process has the advantages of reconfigurability and rapid-prototyping to facilitate preparing acoustofluidic devices for wider applications.

Original languageEnglish
Article number074003
JournalJournal of Micromechanics and Microengineering
Volume31
Issue number7
DOIs
Publication statusPublished - Jul 2021
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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