A randomised controlled trial of a mindfulness intervention for men with advanced prostate cancer

Suzanne K. Chambers; David P. Smith; Martin Berry; Stephen J. Lepore; Elizabeth Foley; Samantha Clutton; Robert McDowall; Stefano Occhipinti; Mark Frydenberg; Robert A. Gardiner

doi:10.1186/1471-2407-13-89

A randomised controlled trial of a mindfulness intervention for men with advanced prostate cancer

Suzanne K. Chambers, David P. Smith, Martin Berry, Stephen J. Lepore, Elizabeth Foley, Samantha Clutton, Robert McDowall, Stefano Occhipinti, Mark Frydenberg, Robert A. Gardiner

Department of English and Communication

Research output: Journal article publication › Journal article › Academic research › peer-review

16 Citations (Scopus)

Abstract

Background: Prostate cancer is the most common male cancer in developed countries, and in Australia approximately one-fifth of men with prostate cancer have advanced disease. By comparison to men with localised prostate cancer, men with advanced disease report higher levels of psychological distress; poorer quality of life; and have an increased risk of suicide. To date no psychological intervention research specifically targeting men with advanced prostate cancer has been reported. In this paper we present the protocol of a current randomised controlled trial to assess the effectiveness of a professionally-led mindfulness-based cognitive therapy (MBCT) group intervention to improve psychological well-being in men with advanced prostate cancer.Methods/design: Ninety-five men per condition (190 men in total) will be recruited through clinicians in the Australian and New Zealand Urogenital and Prostate Cancer Trials Group and in major treatment centres in Queensland, New South Wales, Victoria and Western Australia. Patients are randomised to: (1) tele-based MBCT intervention or (2) patient education. A series of previously validated and reliable self-report measures will be administered to men at four time points: baseline/recruitment, and at 3, 6, and 9 months after recruitment and intervention commencement. Engagement with the principles of mindfulness and adherence to practice will be included as potential mediators of intervention effect. Primary outcomes are anxiety, depression and cancer-specific distress. Secondary outcomes are health-related quality of life (QoL) and benefit finding. Disease variables (e.g. cancer grade, stage) will be assessed through medical records.Discussion: This study will address a critical but as yet unanswered research question: to identify an effective way to reduce psychological distress; and improve the quality of life for men with advanced prostate cancer.Trial registration: http://ACTRN12612000306819.

Original language	English
Article number	89
Journal	BMC Cancer
Volume	13
DOIs	https://doi.org/10.1186/1471-2407-13-89
Publication status	Published - 26 Feb 2013

Keywords

Health outcomes
Mental health
Prostate cancer
Psychological distress
Quality of life
Randomised controlled trial (RCT)
Supportive care

ASJC Scopus subject areas

Genetics
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1186/1471-2407-13-89

Cite this

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title = "A randomised controlled trial of a mindfulness intervention for men with advanced prostate cancer",

abstract = "Background: Prostate cancer is the most common male cancer in developed countries, and in Australia approximately one-fifth of men with prostate cancer have advanced disease. By comparison to men with localised prostate cancer, men with advanced disease report higher levels of psychological distress; poorer quality of life; and have an increased risk of suicide. To date no psychological intervention research specifically targeting men with advanced prostate cancer has been reported. In this paper we present the protocol of a current randomised controlled trial to assess the effectiveness of a professionally-led mindfulness-based cognitive therapy (MBCT) group intervention to improve psychological well-being in men with advanced prostate cancer.Methods/design: Ninety-five men per condition (190 men in total) will be recruited through clinicians in the Australian and New Zealand Urogenital and Prostate Cancer Trials Group and in major treatment centres in Queensland, New South Wales, Victoria and Western Australia. Patients are randomised to: (1) tele-based MBCT intervention or (2) patient education. A series of previously validated and reliable self-report measures will be administered to men at four time points: baseline/recruitment, and at 3, 6, and 9 months after recruitment and intervention commencement. Engagement with the principles of mindfulness and adherence to practice will be included as potential mediators of intervention effect. Primary outcomes are anxiety, depression and cancer-specific distress. Secondary outcomes are health-related quality of life (QoL) and benefit finding. Disease variables (e.g. cancer grade, stage) will be assessed through medical records.Discussion: This study will address a critical but as yet unanswered research question: to identify an effective way to reduce psychological distress; and improve the quality of life for men with advanced prostate cancer.Trial registration: http://ACTRN12612000306819.",

keywords = "Health outcomes, Mental health, Prostate cancer, Psychological distress, Quality of life, Randomised controlled trial (RCT), Supportive care",

author = "Chambers, {Suzanne K.} and Smith, {David P.} and Martin Berry and Lepore, {Stephen J.} and Elizabeth Foley and Samantha Clutton and Robert McDowall and Stefano Occhipinti and Mark Frydenberg and Gardiner, {Robert A.}",

note = "Funding Information: This project was funded by the Australian National Health and Medical Research Council (ID APP1024989), and undertaken in partnership with the Australian and New Zealand Urogenital and Prostate (ANZUP) Cancer Trials Group and Cancer Council Queensland and New South Wales. We gratefully acknowledge the support of the Prostate Cancer Foundation of Australia; the Urological Society of Australia and New Zealand; of Professor Ian Davis, Dr Peter Heathcote, Professor Nigel Spry, Associate Professor Martin Stockler, and Dr John Yaxley as associate investigators; and of Mr Bill McHugh and Mr Peter Dornan as consumer advisors.",

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AU - Berry, Martin

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AU - McDowall, Robert

AU - Occhipinti, Stefano

AU - Frydenberg, Mark

AU - Gardiner, Robert A.

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N2 - Background: Prostate cancer is the most common male cancer in developed countries, and in Australia approximately one-fifth of men with prostate cancer have advanced disease. By comparison to men with localised prostate cancer, men with advanced disease report higher levels of psychological distress; poorer quality of life; and have an increased risk of suicide. To date no psychological intervention research specifically targeting men with advanced prostate cancer has been reported. In this paper we present the protocol of a current randomised controlled trial to assess the effectiveness of a professionally-led mindfulness-based cognitive therapy (MBCT) group intervention to improve psychological well-being in men with advanced prostate cancer.Methods/design: Ninety-five men per condition (190 men in total) will be recruited through clinicians in the Australian and New Zealand Urogenital and Prostate Cancer Trials Group and in major treatment centres in Queensland, New South Wales, Victoria and Western Australia. Patients are randomised to: (1) tele-based MBCT intervention or (2) patient education. A series of previously validated and reliable self-report measures will be administered to men at four time points: baseline/recruitment, and at 3, 6, and 9 months after recruitment and intervention commencement. Engagement with the principles of mindfulness and adherence to practice will be included as potential mediators of intervention effect. Primary outcomes are anxiety, depression and cancer-specific distress. Secondary outcomes are health-related quality of life (QoL) and benefit finding. Disease variables (e.g. cancer grade, stage) will be assessed through medical records.Discussion: This study will address a critical but as yet unanswered research question: to identify an effective way to reduce psychological distress; and improve the quality of life for men with advanced prostate cancer.Trial registration: http://ACTRN12612000306819.

AB - Background: Prostate cancer is the most common male cancer in developed countries, and in Australia approximately one-fifth of men with prostate cancer have advanced disease. By comparison to men with localised prostate cancer, men with advanced disease report higher levels of psychological distress; poorer quality of life; and have an increased risk of suicide. To date no psychological intervention research specifically targeting men with advanced prostate cancer has been reported. In this paper we present the protocol of a current randomised controlled trial to assess the effectiveness of a professionally-led mindfulness-based cognitive therapy (MBCT) group intervention to improve psychological well-being in men with advanced prostate cancer.Methods/design: Ninety-five men per condition (190 men in total) will be recruited through clinicians in the Australian and New Zealand Urogenital and Prostate Cancer Trials Group and in major treatment centres in Queensland, New South Wales, Victoria and Western Australia. Patients are randomised to: (1) tele-based MBCT intervention or (2) patient education. A series of previously validated and reliable self-report measures will be administered to men at four time points: baseline/recruitment, and at 3, 6, and 9 months after recruitment and intervention commencement. Engagement with the principles of mindfulness and adherence to practice will be included as potential mediators of intervention effect. Primary outcomes are anxiety, depression and cancer-specific distress. Secondary outcomes are health-related quality of life (QoL) and benefit finding. Disease variables (e.g. cancer grade, stage) will be assessed through medical records.Discussion: This study will address a critical but as yet unanswered research question: to identify an effective way to reduce psychological distress; and improve the quality of life for men with advanced prostate cancer.Trial registration: http://ACTRN12612000306819.

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KW - Prostate cancer

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KW - Supportive care

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A randomised controlled trial of a mindfulness intervention for men with advanced prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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