Green building is an effective means to implement economic, social and environmental sustainability in the construction industry. Site planning and site design (SP&SD) is a key issue in forming sustainable site in green building development. There is lack of a comprehensive framework for SP&SD in green buildings according to previous research. In this research study, a preliminary framework for SP&SD was explored. To develop this framework, a desk study by the authors was conducted to and major variables in SP&SD of green buildings were identified. In addition, 12 face-to-face interviews with practitioners in green building development were carried out. Through the interview, the process of SP&SD in green buildings was discussed, and the design principles, relationships between stakeholders, and effective planning and design approaches were explored respectively. Content analysis and coding were adopted to analyze the interview data. A preliminary framework for SP&SD was established based on previous literature and the interviews, which can provide references for effective SP&SD in green building development. In future research, the validation of the framework can be further explored based on case studies.