A potential water-soluble ytterbium-based porphyrin-cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

Jing Xiang Zhang; Hongguang Li; Chi Fai Chan; Rongfeng Lan; Wai Lun Chan; Ga Lai Law; Wai Kwok Wong; Ka Leung Wong

doi:10.1039/c2cc34963a

A potential water-soluble ytterbium-based porphyrin-cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

Jing Xiang Zhang, Hongguang Li, Chi Fai Chan, Rongfeng Lan, Wai Lun Chan, Ga Lai Law, Wai Kwok Wong, Ka Leung Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

50 Citations (Scopus)

Abstract

An amphiphilic water-soluble ytterbium complex which is photo-selective, functional and Golgi apparatus specific has been designed as a responsive dual probe capable of sensitizing emission within the biological window (660 and 750 nm), generating the singlet oxygen (ΦΔ= 0.45) and triggering local cell damage only upon exposure to visible and near-infrared laser excitation.

Original language	English
Pages (from-to)	9646-9648
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	77
DOIs	https://doi.org/10.1039/c2cc34963a
Publication status	Published - 7 Oct 2012

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc34963a

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AU - Li, Hongguang

AU - Chan, Chi Fai

AU - Lan, Rongfeng

AU - Chan, Wai Lun

AU - Law, Ga Lai

AU - Wong, Wai Kwok

AU - Wong, Ka Leung

PY - 2012/10/7

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AB - An amphiphilic water-soluble ytterbium complex which is photo-selective, functional and Golgi apparatus specific has been designed as a responsive dual probe capable of sensitizing emission within the biological window (660 and 750 nm), generating the singlet oxygen (ΦΔ= 0.45) and triggering local cell damage only upon exposure to visible and near-infrared laser excitation.

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DO - 10.1039/c2cc34963a

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JO - Chemical Communications

JF - Chemical Communications

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A potential water-soluble ytterbium-based porphyrin-cyclen dual bio-probe for Golgi apparatus imaging and photodynamic therapy

Abstract

ASJC Scopus subject areas

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