A portable ultrasound system for non-invasive ultrasonic neuro-stimulation

Weibao Qiu, Juan Zhou, Yan Chen, Min Su, Guofeng Li, Huixia Zhao, Xianyi Gu, De Meng, Congzhi Wang, Yang Xiao, Kwok Ho Lam, Jiyan Dai, Hairong Zheng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

35 Citations (Scopus)


Fundamental insights into the function of the neural circuits often follows from the advances in methodologies and tools for neuroscience. Electrode- and optical- based stimulation methods have been used widely for neuro-modulation with high resolution. However, they are suffering from inherent invasive surgical procedure. Ultrasound has been proved as a promising technology for neuro-stimulation in a non-invasive manner. However, no portable ultrasound system has been developed particularly for neuro-stimulation. The utilities used currently are assembled by traditional functional generator, power amplifier, and general transducer, therefore, resulting in lack of flexibility. This paper presents a portable system to achieve ultrasonic neuro-stimulation to satisfy various studies. The system incorporated a high voltage waveform generator and a matching circuit that were optimized for neuro-stimulation. A new switching mode power amplifier was designed and fabricated. The noise generated by the power amplifier was reduced (about 30 dB), and the size and weight were smaller in contrast with commercial equipment. In addition, a miniaturized ultrasound transducer was fabricated using Pb(Mg1/3Nb2/3)O3-PbTiO3(PMN-PT) 1–3 composite single crystal for the improved ultrasonic performance. The spatial peak temporal average pressure was higher than 250 kPa in the range of 0.5–5 MHz. In vitro and in vivo studies were conducted to show the performance of the system.
Original languageEnglish
Pages (from-to)2509-2515
Number of pages7
JournalIEEE Transactions on Neural Systems and Rehabilitation Engineering
Issue number12
Publication statusPublished - 1 Dec 2017


  • Neuro-stimulation
  • Non-invasive
  • Portable
  • Ultrasound stimulation
  • Ultrasound stimulation system

ASJC Scopus subject areas

  • General Neuroscience
  • Biomedical Engineering
  • Computer Science Applications


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