A pilot study on the corneal biomechanical changes in short-term orthokeratology

Davie Chen, Kwok Cheung Andrew Lam, Hie Hua Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

47 Citations (Scopus)


Purpose: To investigate the biomechanical changes in the cornea, in terms of corneal hysteresis (CH) and corneal resistance factor (CRF), with short-term orthokeratology (ortho-k) treatment, using the Ocular Response Analyser (ORA; Reichert Ophthalmic Instruments, Buffalo, NY, USA). Methods: Twenty young myopes wore ortho-k lenses in four different sessions: 15, 30, 60 min and overnight respectively. Except for the overnight session which was always the final trial, those sessions were randomly assigned with a 1-week washout period in between. CH and CRF were measured using the ORA and results were compared between the baseline and after each wearing session. Results: The mean baseline CH and CRF were 11.1 ± 1.0 mmHg and 10.7 ± 1.3 mmHg, respectively. There was no significant change in CH throughout the study, while a decreasing trend of CRF was shown. Paired t-test with Bonferroni correction found a significantly reduced CRF of 10.1 mmHg after overnight wear. Conclusions: Short-term ortho-k treatment was shown to alter some corneal biomechanical properties. CRF was shown to decrease with increasing duration of lens wear. Further study is warranted to investigate the long term effect on corneal biomechanics from ortho-k treatment.
Original languageEnglish
Pages (from-to)464-471
Number of pages8
JournalOphthalmic and Physiological Optics
Issue number4
Publication statusPublished - 1 Jul 2009


  • Corneal biomechanics
  • Corneal hysteresis
  • Corneal resistance factor
  • Orthokeratology

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry
  • Sensory Systems


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