A pH/GSH/Glucose Responsive Nanozyme for Tumor Cascade Amplified Starvation and Chemodynamic Theranostics

Lihua Li; Zefeng Lin; Xingyi Xu; Wanshun Wang; Hu Chen; Zhibin Feng; Zhongmin Yang; Jianhua Hao

doi:10.1021/acsami.3c05412

A pH/GSH/Glucose Responsive Nanozyme for Tumor Cascade Amplified Starvation and Chemodynamic Theranostics

Lihua Li
, Zefeng Lin
, Xingyi Xu
, Wanshun Wang
, Hu Chen
, Zhibin Feng
, Zhongmin Yang
, Jianhua Hao

Research output: Journal article publication › Journal article › Academic research › peer-review

31 Citations (Scopus)

Abstract

Nanozymes have brought enormous opportunities for disease theranostics. Here, a self-enhanced catalytic nanocrystal based on a bismuth-manganese core-shell nanoflower containing glucose oxide (GOx), termed BDS-GOx@MnO_x, was designed for 4T1 tumor theranostics in vitro and in vivo. The BDS-GOx@MnO_x nanozymes enable enhanced starvation treatment (ST) and chemotherapy (CDT) with high efficacy and exhibit sensitive tumor microenvironment (TME) responsive character for tumor therapy as well as for tumor-enhanced computer tomography (CT) and magnetic resonance (MR) diagnostic imaging. The characters and mechanism of the BDS-GOx@MnO_x nanozymes have also been systematically studied and revealed.

Original language	English
Pages (from-to)	41224-41236
Number of pages	13
Journal	ACS Applied Materials and Interfaces
Volume	15
Issue number	35
DOIs	https://doi.org/10.1021/acsami.3c05412
Publication status	Published - 6 Sept 2023

Keywords

chemodynamic therapy
nanozyme
starvation therapy
tumor imaging
tumor microenvironment responsive

ASJC Scopus subject areas

General Materials Science

More information

10.1021/acsami.3c05412

Cite this

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abstract = "Nanozymes have brought enormous opportunities for disease theranostics. Here, a self-enhanced catalytic nanocrystal based on a bismuth-manganese core-shell nanoflower containing glucose oxide (GOx), termed BDS-GOx@MnOx, was designed for 4T1 tumor theranostics in vitro and in vivo. The BDS-GOx@MnOx nanozymes enable enhanced starvation treatment (ST) and chemotherapy (CDT) with high efficacy and exhibit sensitive tumor microenvironment (TME) responsive character for tumor therapy as well as for tumor-enhanced computer tomography (CT) and magnetic resonance (MR) diagnostic imaging. The characters and mechanism of the BDS-GOx@MnOx nanozymes have also been systematically studied and revealed.",

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AU - Li, Lihua

AU - Lin, Zefeng

AU - Xu, Xingyi

AU - Wang, Wanshun

AU - Chen, Hu

AU - Feng, Zhibin

AU - Yang, Zhongmin

AU - Hao, Jianhua

PY - 2023/9/6

Y1 - 2023/9/6

N2 - Nanozymes have brought enormous opportunities for disease theranostics. Here, a self-enhanced catalytic nanocrystal based on a bismuth-manganese core-shell nanoflower containing glucose oxide (GOx), termed BDS-GOx@MnOx, was designed for 4T1 tumor theranostics in vitro and in vivo. The BDS-GOx@MnOx nanozymes enable enhanced starvation treatment (ST) and chemotherapy (CDT) with high efficacy and exhibit sensitive tumor microenvironment (TME) responsive character for tumor therapy as well as for tumor-enhanced computer tomography (CT) and magnetic resonance (MR) diagnostic imaging. The characters and mechanism of the BDS-GOx@MnOx nanozymes have also been systematically studied and revealed.

AB - Nanozymes have brought enormous opportunities for disease theranostics. Here, a self-enhanced catalytic nanocrystal based on a bismuth-manganese core-shell nanoflower containing glucose oxide (GOx), termed BDS-GOx@MnOx, was designed for 4T1 tumor theranostics in vitro and in vivo. The BDS-GOx@MnOx nanozymes enable enhanced starvation treatment (ST) and chemotherapy (CDT) with high efficacy and exhibit sensitive tumor microenvironment (TME) responsive character for tumor therapy as well as for tumor-enhanced computer tomography (CT) and magnetic resonance (MR) diagnostic imaging. The characters and mechanism of the BDS-GOx@MnOx nanozymes have also been systematically studied and revealed.

KW - chemodynamic therapy

KW - nanozyme

KW - starvation therapy

KW - tumor imaging

KW - tumor microenvironment responsive

UR - https://www.scopus.com/pages/publications/85169847789

U2 - 10.1021/acsami.3c05412

DO - 10.1021/acsami.3c05412

M3 - Journal article

C2 - 37615578

AN - SCOPUS:85169847789

SN - 1944-8244

VL - 15

SP - 41224

EP - 41236

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 35

ER -

A pH/GSH/Glucose Responsive Nanozyme for Tumor Cascade Amplified Starvation and Chemodynamic Theranostics

Abstract

Keywords

ASJC Scopus subject areas

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