Abstract
Nanozymes have brought enormous opportunities for disease theranostics. Here, a self-enhanced catalytic nanocrystal based on a bismuth-manganese core-shell nanoflower containing glucose oxide (GOx), termed BDS-GOx@MnOx, was designed for 4T1 tumor theranostics in vitro and in vivo. The BDS-GOx@MnOx nanozymes enable enhanced starvation treatment (ST) and chemotherapy (CDT) with high efficacy and exhibit sensitive tumor microenvironment (TME) responsive character for tumor therapy as well as for tumor-enhanced computer tomography (CT) and magnetic resonance (MR) diagnostic imaging. The characters and mechanism of the BDS-GOx@MnOx nanozymes have also been systematically studied and revealed.
Original language | English |
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Pages (from-to) | 41224-41236 |
Number of pages | 13 |
Journal | ACS Applied Materials and Interfaces |
Volume | 15 |
Issue number | 35 |
DOIs | |
Publication status | Published - 6 Sept 2023 |
Keywords
- chemodynamic therapy
- nanozyme
- starvation therapy
- tumor imaging
- tumor microenvironment responsive
ASJC Scopus subject areas
- General Materials Science