A pH/GSH/Glucose Responsive Nanozyme for Tumor Cascade Amplified Starvation and Chemodynamic Theranostics

Lihua Li, Zefeng Lin, Xingyi Xu, Wanshun Wang, Hu Chen, Zhibin Feng, Zhongmin Yang, Jianhua Hao

Research output: Journal article publicationJournal articleAcademic researchpeer-review

17 Citations (Scopus)

Abstract

Nanozymes have brought enormous opportunities for disease theranostics. Here, a self-enhanced catalytic nanocrystal based on a bismuth-manganese core-shell nanoflower containing glucose oxide (GOx), termed BDS-GOx@MnOx, was designed for 4T1 tumor theranostics in vitro and in vivo. The BDS-GOx@MnOx nanozymes enable enhanced starvation treatment (ST) and chemotherapy (CDT) with high efficacy and exhibit sensitive tumor microenvironment (TME) responsive character for tumor therapy as well as for tumor-enhanced computer tomography (CT) and magnetic resonance (MR) diagnostic imaging. The characters and mechanism of the BDS-GOx@MnOx nanozymes have also been systematically studied and revealed.

Original languageEnglish
Pages (from-to)41224-41236
Number of pages13
JournalACS Applied Materials and Interfaces
Volume15
Issue number35
DOIs
Publication statusPublished - 6 Sept 2023

Keywords

  • chemodynamic therapy
  • nanozyme
  • starvation therapy
  • tumor imaging
  • tumor microenvironment responsive

ASJC Scopus subject areas

  • General Materials Science

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