@article{8c3fc42dfc24428896ced61aa4aa9e62,
title = "A pH-Dependent rhodamine fluorophore with antiproliferative activity of bladder cancer in Vitro/Vivo and apoptosis mechanism",
abstract = "Herein, 26 rhodamine fluorophores were synthesized from readily available Rh-6G and relative amines at room temperature with good selectivity, functional groups compatibility and high yields. We found that one of them 3f showed pH-dependent anticancer bioactivity, with cell viability of 68.4% under pH 6.5 and 83.2% under pH 7.5, LDH fold change of 42.8% under pH 6.5 and 26.4% under pH 7.5 in 22.35 μM in human bladder cancer cell line EJ. Besides, 3f showed anticancer bioactivity in vivo towards human bladder cancer, by triggering apoptosis through mitochondrial pathway.",
keywords = "Anti-bladder cancer, Cell image, NMIBC, pH on-off, Rhodamine",
author = "Dingheng Lu and Tianbao Yang and Niu Tang and Chenghan Li and Yarong Song and Liang Wang and Wong, {Wai Yeung} and Yin, {Shuang Feng} and Yifei Xing and Nobuaki Kambe and Renhua Qiu",
note = "Funding Information: The authors thank the Natural Science Foundation of China (Nos. 21676076 , 21878071 , 21971060 ), Hu-Xiang High Talent of Hunan Province ( 2018RS3042 ), and Recruitment Program for Foreign Experts of China ( WQ20164300353 ) for financial support. W.-Y.W. is grateful to the financial support from Hong Kong Research Grants Council ( PolyU153058/19P ), the Hong Kong Polytechnic University (1-ZE1C) and Ms Clarea Au for the Endowed Professorship in Energy (847S). Publisher Copyright: {\textcopyright} 2022",
year = "2022",
month = jun,
day = "5",
doi = "10.1016/j.ejmech.2022.114293",
language = "English",
volume = "236",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier Masson SAS",
}
