Abstract
Reductive cleavage of the N{single bond}O bond of isoxazolidine ring with catalytic hydrogenation over Raney nickel was described. Bicyclic isoxazolidines could be effectively converted into the corresponding 1,3-amino-alcohol possessing a sultone or sultam moiety with high conversion and yield when the hydrogenation was catalyzed by freshly prepared Raney nickel under a pressure of 40 psi in the presence of triethylamine.
Original language | English |
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Pages (from-to) | 629-632 |
Number of pages | 4 |
Journal | Chinese Chemical Letters |
Volume | 18 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Jun 2007 |
Externally published | Yes |
Keywords
- 1,3-Amino-alcohol
- Hydrogenation
- Isoxazolidine
- Raney nickel
ASJC Scopus subject areas
- General Chemistry