A novel reductive ring-opening reaction of isoxazolidine to form functionalized 1,3-amino-alcohol

Hong Kui Zhang, Wing Hong Chan, Albert W M Lee, Ping Fang Xia, Wai Yeung Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

3 Citations (Scopus)

Abstract

Reductive cleavage of the N{single bond}O bond of isoxazolidine ring with catalytic hydrogenation over Raney nickel was described. Bicyclic isoxazolidines could be effectively converted into the corresponding 1,3-amino-alcohol possessing a sultone or sultam moiety with high conversion and yield when the hydrogenation was catalyzed by freshly prepared Raney nickel under a pressure of 40 psi in the presence of triethylamine.
Original languageEnglish
Pages (from-to)629-632
Number of pages4
JournalChinese Chemical Letters
Volume18
Issue number6
DOIs
Publication statusPublished - 1 Jun 2007
Externally publishedYes

Keywords

  • 1,3-Amino-alcohol
  • Hydrogenation
  • Isoxazolidine
  • Raney nickel

ASJC Scopus subject areas

  • Chemistry(all)

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