A novel modulated excitation imaging system for microultrasound

Weibao Qiu, Yanyan Yu, Fu Keung Tsang, Hairong Zheng, Lei Sun

Research output: Journal article publicationJournal articleAcademic researchpeer-review

16 Citations (Scopus)


Microultrasound (micro-US), also known as ultrasound biomicroscope, is able to delineate small structures with fine spatial resolution. However, micro-US suffers limited depth of penetration due to significantly large attenuation at high frequencies. Modulated excitation imaging has displayed the capability to improve the penetration depth, while maintaining the spatial resolution. But the effectiveness of this technique in micro-US has not been fully demonstrated. In addition, the current modulated excitation imaging systems for micro-US are designed for specific excitation method, therefore, lack of flexibility, and are typically bulky and expensive. This paper presents the development of a novel system to achieve modulated excitation imaging with high programmability and flexibility to satisfy various micro-US studies. It incorporates a high-voltage arbitrary waveform generator for producing desired excitation waveform, and a programmable imaging receiver implemented by the state-of-the-art electronics and field-programmable gate array. Test results show that the proposed modulated excitation imaging system can acquire up to 20 dB signal-to-noise ratio improvement and 83% increase of penetration depth in contrast to traditional short-pulse imaging method. In vivo experiment on the dorsal skin of a human hand demonstrates good performance of the programmable modulated excitation imaging system.
Original languageEnglish
Article number6428625
Pages (from-to)1884-1890
Number of pages7
JournalIEEE Transactions on Biomedical Engineering
Issue number7
Publication statusPublished - 15 Jul 2013


  • Arbitrary waveform generator
  • field-programmable gate array (FPGA)
  • microultrasound (micro-US)
  • modulated excitation imaging
  • programmable and real-time imaging

ASJC Scopus subject areas

  • Biomedical Engineering


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