A novel method to obtain modulus image of soft tissues using ultrasound water jet indentation: A phantom study

Min Hua Lu, Yongping Zheng, Qing Hua Huang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

21 Citations (Scopus)


The alteration of tissue stiffness is generally known to be associated with pathological changes. Ultrasound indentation is one of the methods that can be used to assess the mechanical properties of the soft tissues. It uses a flat-ended ultrasound transducer to directly contact the tissue to sense tissue deformation under an applied load. This paper introduced a novel noncontact ultrasound indentation system using water jet compression. The key idea was to utilize a water jet as the indenter as well as the coupling medium for propagation of the ultrasound beam. High frequency focused ultrasound (20 MHz) was used to measure the indentation deformation at a microscopic level. It has been demonstrated that the system could effectively assess the tissue-mimic phantoms with different stiffness. Water jet coupling allows the system to conduct C-scan on soft tissues rapidly and conveniently. By applying different pressures while taking C-scan sequences, the modulus images of the phantoms could be obtained based on the applied pressure and the phantom deformation and thickness. This paper presented the preliminary results on gel phantoms. The spatial resolution, the contrast resolution of the measurements and the reproducibility of the results were also discussed.
Original languageEnglish
Article number16
Pages (from-to)114-121
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Issue number1
Publication statusPublished - 1 Jan 2007


  • Articular cartilage
  • Elasticity imaging
  • Elastography
  • Elastomicroscopy
  • High-frequency ultrasound
  • Modulus image
  • Tissue
  • Ultrasound indentation
  • Water jet

ASJC Scopus subject areas

  • Biomedical Engineering


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