Abstract
Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress that may be regulated by growth factor such as Endothelin-1 (ET-1). The majority of existing techniques to monitor hypertrophy in vitro are based on florescence probes designed to show morphological and biochemical alterations indicative of cardiomyocyte hypertrophy. In this work, a new cardiomyocyte-based impedance sensing system with the assistance of dielectrophoresis (DEP) cell concentration is developed to monitor the dynamics process of ET-1 induced cardiomyocyte hypertrophy. This device can increase the sensitivity of the impedance system and also has the potential to reduce the time for detection by a significant factor.
Original language | English |
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Pages (from-to) | 504-509 |
Number of pages | 6 |
Journal | Sensors and Actuators, A: Physical |
Volume | 136 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 May 2007 |
Keywords
- Cardiac hypertrophy
- Endothelin-1 (ET-1)
- Impedance sensing
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Mechanical Engineering
- Instrumentation