A novel impedance assay for cardiac myocyte hypertrophy sensing

Mo Yang, Xin Zhang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

9 Citations (Scopus)

Abstract

Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress that may be regulated by growth factor such as Endothelin-1 (ET-1). The majority of existing techniques to monitor hypertrophy in vitro are based on florescence probes designed to show morphological and biochemical alterations indicative of cardiomyocyte hypertrophy. In this work, a new cardiomyocyte-based impedance sensing system with the assistance of dielectrophoresis (DEP) cell concentration is developed to monitor the dynamics process of ET-1 induced cardiomyocyte hypertrophy. This device can increase the sensitivity of the impedance system and also has the potential to reduce the time for detection by a significant factor.
Original languageEnglish
Pages (from-to)504-509
Number of pages6
JournalSensors and Actuators, A: Physical
Volume136
Issue number2
DOIs
Publication statusPublished - 1 May 2007

Keywords

  • Cardiac hypertrophy
  • Endothelin-1 (ET-1)
  • Impedance sensing

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Instrumentation

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