A novel impedance assay for cardiac myocyte hypertrophy sensing

Mo Yang; Xin Zhang

doi:10.1016/j.sna.2006.09.014

A novel impedance assay for cardiac myocyte hypertrophy sensing

Mo Yang, Xin Zhang

Research output: Journal article publication › Journal article › Academic research › peer-review

10 Citations (Scopus)

Abstract

Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress that may be regulated by growth factor such as Endothelin-1 (ET-1). The majority of existing techniques to monitor hypertrophy in vitro are based on florescence probes designed to show morphological and biochemical alterations indicative of cardiomyocyte hypertrophy. In this work, a new cardiomyocyte-based impedance sensing system with the assistance of dielectrophoresis (DEP) cell concentration is developed to monitor the dynamics process of ET-1 induced cardiomyocyte hypertrophy. This device can increase the sensitivity of the impedance system and also has the potential to reduce the time for detection by a significant factor.

Original language	English
Pages (from-to)	504-509
Number of pages	6
Journal	Sensors and Actuators, A: Physical
Volume	136
Issue number	2
DOIs	https://doi.org/10.1016/j.sna.2006.09.014
Publication status	Published - 1 May 2007

Keywords

Cardiac hypertrophy
Endothelin-1 (ET-1)
Impedance sensing

ASJC Scopus subject areas

Electrical and Electronic Engineering
Mechanical Engineering
Instrumentation

More information

10.1016/j.sna.2006.09.014

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AB - Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress that may be regulated by growth factor such as Endothelin-1 (ET-1). The majority of existing techniques to monitor hypertrophy in vitro are based on florescence probes designed to show morphological and biochemical alterations indicative of cardiomyocyte hypertrophy. In this work, a new cardiomyocyte-based impedance sensing system with the assistance of dielectrophoresis (DEP) cell concentration is developed to monitor the dynamics process of ET-1 induced cardiomyocyte hypertrophy. This device can increase the sensitivity of the impedance system and also has the potential to reduce the time for detection by a significant factor.

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ER -

A novel impedance assay for cardiac myocyte hypertrophy sensing

Abstract

Keywords

ASJC Scopus subject areas

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