A novel impedance assay for cardiac myocyte hypertrophy sensing

Mo Yang; Xin Zhang

doi:10.1016/j.sna.2006.09.014

A novel impedance assay for cardiac myocyte hypertrophy sensing

Mo Yang, Xin Zhang

Research output: Journal article publication › Journal article › Academic research › peer-review

10 Citations (Scopus)

Abstract

Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress that may be regulated by growth factor such as Endothelin-1 (ET-1). The majority of existing techniques to monitor hypertrophy in vitro are based on florescence probes designed to show morphological and biochemical alterations indicative of cardiomyocyte hypertrophy. In this work, a new cardiomyocyte-based impedance sensing system with the assistance of dielectrophoresis (DEP) cell concentration is developed to monitor the dynamics process of ET-1 induced cardiomyocyte hypertrophy. This device can increase the sensitivity of the impedance system and also has the potential to reduce the time for detection by a significant factor.

Original language	English
Pages (from-to)	504-509
Number of pages	6
Journal	Sensors and Actuators, A: Physical
Volume	136
Issue number	2
DOIs	https://doi.org/10.1016/j.sna.2006.09.014
Publication status	Published - 1 May 2007

Keywords

Cardiac hypertrophy
Endothelin-1 (ET-1)
Impedance sensing

ASJC Scopus subject areas

Electrical and Electronic Engineering
Mechanical Engineering
Instrumentation

More information

10.1016/j.sna.2006.09.014

Cite this

@article{b398c1178f3d46d3b6bf26f4d47423ed,

title = "A novel impedance assay for cardiac myocyte hypertrophy sensing",

abstract = "Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress that may be regulated by growth factor such as Endothelin-1 (ET-1). The majority of existing techniques to monitor hypertrophy in vitro are based on florescence probes designed to show morphological and biochemical alterations indicative of cardiomyocyte hypertrophy. In this work, a new cardiomyocyte-based impedance sensing system with the assistance of dielectrophoresis (DEP) cell concentration is developed to monitor the dynamics process of ET-1 induced cardiomyocyte hypertrophy. This device can increase the sensitivity of the impedance system and also has the potential to reduce the time for detection by a significant factor.",

keywords = "Cardiac hypertrophy, Endothelin-1 (ET-1), Impedance sensing",

author = "Mo Yang and Xin Zhang",

year = "2007",

month = may,

day = "1",

doi = "10.1016/j.sna.2006.09.014",

language = "English",

volume = "136",

pages = "504--509",

journal = "Sensors and Actuators A: Physical",

issn = "0924-4247",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - A novel impedance assay for cardiac myocyte hypertrophy sensing

AU - Yang, Mo

AU - Zhang, Xin

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress that may be regulated by growth factor such as Endothelin-1 (ET-1). The majority of existing techniques to monitor hypertrophy in vitro are based on florescence probes designed to show morphological and biochemical alterations indicative of cardiomyocyte hypertrophy. In this work, a new cardiomyocyte-based impedance sensing system with the assistance of dielectrophoresis (DEP) cell concentration is developed to monitor the dynamics process of ET-1 induced cardiomyocyte hypertrophy. This device can increase the sensitivity of the impedance system and also has the potential to reduce the time for detection by a significant factor.

AB - Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress that may be regulated by growth factor such as Endothelin-1 (ET-1). The majority of existing techniques to monitor hypertrophy in vitro are based on florescence probes designed to show morphological and biochemical alterations indicative of cardiomyocyte hypertrophy. In this work, a new cardiomyocyte-based impedance sensing system with the assistance of dielectrophoresis (DEP) cell concentration is developed to monitor the dynamics process of ET-1 induced cardiomyocyte hypertrophy. This device can increase the sensitivity of the impedance system and also has the potential to reduce the time for detection by a significant factor.

KW - Cardiac hypertrophy

KW - Endothelin-1 (ET-1)

KW - Impedance sensing

UR - http://www.scopus.com/inward/record.url?scp=34247580114&partnerID=8YFLogxK

U2 - 10.1016/j.sna.2006.09.014

DO - 10.1016/j.sna.2006.09.014

M3 - Journal article

SN - 0924-4247

VL - 136

SP - 504

EP - 509

JO - Sensors and Actuators A: Physical

JF - Sensors and Actuators A: Physical

IS - 2

ER -

A novel impedance assay for cardiac myocyte hypertrophy sensing

Abstract

Keywords

ASJC Scopus subject areas

More information

Other files and links

Fingerprint

Cite this