A novel green gelatin-agar microencapsulation system with P. urinaria as an improved anti-A. niger model

Pik Ling Lam, Stanton Hon Lung Kok, Yiu Wah Ho, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Chor Hing Cheng, Kim Hung Lam, Roberto Gambari, Kenneth Ka Ho Lee, Chung Hin Chui

Research output: Journal article publicationJournal articleAcademic researchpeer-review

17 Citations (Scopus)

Abstract

In this study, a novel green microencapsulation system was used to develop Phyllanthus urinaria (PU) extract containing microcapsules. Agar was used with gelatin as the wall matrix materials of microcapsules to prevent the use of toxic crosslinker formaldehyde. Microencapsulated PU extract was developed to improve the potential antifungal activities of PU water extracts. The active components and surface morphology of PU extract containing microcapsules were analyzed by liquid chromatography/mass spectrometry and scanning electron microscopy, respectively. The in vitro release study demonstrated that approximately 80% of drug was released after 120 h. PU loaded microcapsules were shown to have a stronger anti-Aspergillus niger activity than the free drug.

Original languageEnglish
Pages (from-to)877-880
Number of pages4
JournalCarbohydrate Polymers
Volume92
Issue number1
DOIs
Publication statusPublished - 30 Jan 2013

Keywords

  • Agar
  • Aspergillus niger
  • Gelatin
  • Microcapsules
  • Phyllanthus urinaria

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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