A new family of tunable indolylphosphine ligands by one-pot assembly and their applications in Suzuki-Miyaura coupling of aryl chlorides

Chau Ming So; Chung Chiu Yeung; Chak Po Lau; Fuk Yee Kwong

doi:10.1021/jo801544w

A new family of tunable indolylphosphine ligands by one-pot assembly and their applications in Suzuki-Miyaura coupling of aryl chlorides

Chau Ming So, Chung Chiu Yeung, Chak Po Lau, Fuk Yee Kwong (Corresponding Author)

Research output: Journal article publication › Journal article › Academic research › peer-review

19 Citations (Scopus)

Abstract

(Chemical Equation Presented) This study describes a new class of indolylphosphine ligands, which can be easily accessed by a simple one-pot assembly from commercially available indoles, acid chlorides, and chlorophosphines. A combination of these three starting materials provides a high diversification of the ligand structure. The application of this ligand array in palladium-catalyzed Suzuki-Miyaura coupling reaction of aryl chlorides with arylboronic acids is described. A catalyst loading down to 0.01 mol % of Pd can be achieved.

Original language	English
Pages (from-to)	7803-7806
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	73
Issue number	19
DOIs	https://doi.org/10.1021/jo801544w
Publication status	Published - 3 Oct 2008

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo801544w

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abstract = "(Chemical Equation Presented) This study describes a new class of indolylphosphine ligands, which can be easily accessed by a simple one-pot assembly from commercially available indoles, acid chlorides, and chlorophosphines. A combination of these three starting materials provides a high diversification of the ligand structure. The application of this ligand array in palladium-catalyzed Suzuki-Miyaura coupling reaction of aryl chlorides with arylboronic acids is described. A catalyst loading down to 0.01 mol % of Pd can be achieved.",

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A new family of tunable indolylphosphine ligands by one-pot assembly and their applications in Suzuki-Miyaura coupling of aryl chlorides. / So, Chau Ming; Yeung, Chung Chiu; Lau, Chak Po et al.
In: Journal of Organic Chemistry, Vol. 73, No. 19, 03.10.2008, p. 7803-7806.

Research output: Journal article publication › Journal article › Academic research › peer-review

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AU - So, Chau Ming

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AU - Lau, Chak Po

AU - Kwong, Fuk Yee

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AB - (Chemical Equation Presented) This study describes a new class of indolylphosphine ligands, which can be easily accessed by a simple one-pot assembly from commercially available indoles, acid chlorides, and chlorophosphines. A combination of these three starting materials provides a high diversification of the ligand structure. The application of this ligand array in palladium-catalyzed Suzuki-Miyaura coupling reaction of aryl chlorides with arylboronic acids is described. A catalyst loading down to 0.01 mol % of Pd can be achieved.

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A new family of tunable indolylphosphine ligands by one-pot assembly and their applications in Suzuki-Miyaura coupling of aryl chlorides

Abstract

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