A new chiral dipyridylphosphine ligand Xyl-P-Phos and its application in the Ru-catalyzed asymmetric hydrogenation of β-ketoesters

Jing Wu, Hua Chen, Wai Him Kwok, Kim Hung Lam, Zhong Yuan Zhou, Chi Hung Yeung, Albert S.C. Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

70 Citations (Scopus)

Abstract

A new chiral dipyridylphosphine ligand Xyl-P-Phos has been synthesized and the structure of (S)-Xyl-P-Phos oxide has been characterized by single crystal X-ray diffraction. The ruthenium complex of this ligand, Ru(R-Xyl-P-Phos)(C6H6)Cl2, has been found to be a highly active, enantioselective and air-stable catalyst for the asymmetric hydrogenation of β-ketoesters and shows good potential for industrial applications.

Original languageEnglish
Pages (from-to)1539-1543
Number of pages5
JournalTetrahedron Letters
Volume43
Issue number8
DOIs
Publication statusPublished - 18 Feb 2002

Keywords

  • Asymmetric hydrogenation
  • Dipyridylphosphine ligands
  • Ruthenium complex
  • β-ketoester

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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