Abstract
A new chiral dipyridylphosphine ligand Xyl-P-Phos has been synthesized and the structure of (S)-Xyl-P-Phos oxide has been characterized by single crystal X-ray diffraction. The ruthenium complex of this ligand, Ru(R-Xyl-P-Phos)(C6H6)Cl2, has been found to be a highly active, enantioselective and air-stable catalyst for the asymmetric hydrogenation of β-ketoesters and shows good potential for industrial applications.
Original language | English |
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Pages (from-to) | 1539-1543 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 43 |
Issue number | 8 |
DOIs | |
Publication status | Published - 18 Feb 2002 |
Keywords
- Asymmetric hydrogenation
- Dipyridylphosphine ligands
- Ruthenium complex
- β-ketoester
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry