A natural product, resveratrol, protects against high-glucose-induced developmental damage in chicken embryo

Rui Rong Tan, Shi Jie Zhang, Bun Tsoi, Wen Shan Huang, Xiao Ji Zhuang, Xiao Yun Chen, Nan Yao, Zhong Fu Mao, Lu Ping Tang, Qi Wang, Hiroshi Kurihara, Yi Fang Li, Rong Rong He

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)

Abstract

Resveratrol, a famous plant-derived polyphenolic phytoalexin, has been considered to play physiological roles such as antioxidative, neuroprotective, and anticancer effects in adults. However, its antioxidative activity and neuroprotective effect were seldom discussed in the embryonic system. In this study, the effect of resveratrol on chicken embryo development under high glucose and its underlying mechanism of resveratrol were investigated. High glucose administrated to chicken embryo at embryonic Day 1 induced stillbirth, growth retardation, and impaired blood vessel development on yolk sac. However, resveratrol supplementation before glucose exposure showed significant effect on decreasing the death rate, developmental damage, and vessel injury. In addition, oxidative stress was caused by high-glucose exposure, and resveratrol could rescue this high-glucose-induced oxidative stress. Moreover, the neural developmental marker paired box 3 was significantly decreased by high glucose and recovered by resveratrol. Cell cycle-regulated gene expression was also intervened by resveratrol. This study had found an association between resveratrol and hyperglycemia-induced embryonic damage, which suggested a potential protective effect of resveratrol on gestational diabetes.

Original languageEnglish
Pages (from-to)586-594
Number of pages9
JournalJournal of Asian Natural Products Research
Volume17
Issue number5
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Antioxidation
  • Embryo development
  • High glucose
  • Resveratrol

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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