A multicomponent integrative intervention to slow down the progression of mild cognitive impairment: A protocol for a randomized controlled trial

Qiyuan Lyu, Daphne S.K. Cheung, Huilan Lai, Xiaomeng Wang, Jing Qiu, Yuanqiu Huang, Yingchun Zeng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)


Mild cognitive impairment affects 36% of people aged 65 years and over in China, and around 50% transition from mild cognitive impairment to dementia within 3 years. Early intervention can slow down disease progression and thus delay dementia onset. The purpose of this article is to outline the protocol of an ongoing randomized controlled trial in mainland China that will evaluate the effects and feasibility of a 6-month multicomponent integrative intervention on the speed of progression of mild cognitive impairment to dementia. Ninety-six community-dwelling older adults, aged 65 years and older, will be recruited (recruitment will be completed in May 2020), using strict inclusion/exclusion criteria, from two community health service centers in Guangzhou, Guangdong province. Participants will be allocated to receive either the multicomponent integrative intervention or usual care. The core components of the intervention are cognitive training, dietary instruction, physical activity, and management of vascular risk factors. Data are collected at the beginning of the study, then at 1, 3, and 6 months. The primary outcome is cognitive function. The main secondary outcomes are exercise capacity, comprehensive physical capacity, depression, and quality of life. An intention-to-treat analysis will be conducted. The study will be completed in 2021. The multicomponent integrative intervention detailed in this protocol could be incorporated into dementia prevention programs in community health service centers, or other similar settings, to delay the onset of dementia.

Original languageEnglish
Pages (from-to)307-316
Number of pages10
JournalResearch in Nursing and Health
Issue number4
Publication statusPublished - 1 Aug 2020


  • cognitive function
  • dementia
  • quality of life
  • randomized controlled trial

ASJC Scopus subject areas

  • Nursing(all)

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