TY - JOUR
T1 - A multicomponent integrative intervention to slow down the progression of mild cognitive impairment
T2 - A protocol for a randomized controlled trial
AU - Lyu, Qiyuan
AU - Cheung, Daphne S.K.
AU - Lai, Huilan
AU - Wang, Xiaomeng
AU - Qiu, Jing
AU - Huang, Yuanqiu
AU - Zeng, Yingchun
N1 - Funding Information:
The authors would like to thank all the staff in the community centers in Guangzhou. This research was supported by the National Natural Science Foundation of China (71804204), the Natural Science Foundation of Guangdong Province of China (2019A1515011672), and Fundamental Research Funds for the Central Universities (N2017Y05).
Funding Information:
The first author is the project manager and will coordinate the overall management of the project and take charge of database development, training delivery, overseeing the entire trial, and data quality assessment. At each center, a project group, comprising a senior community nurse and four research assistants, has been assembled to (a) recruit patients; (b) deliver the intervention; and (c) collect data for assessment of outcomes. The trial has been approved by the Human Subjects Ethics Committee of University (L2018ZSLYEC‐122), is registered with the Chinese Clinical Trial Registry (ChiCTR1900026042), and is being funded by the National Natural Science Foundation of China (71804204), the Natural Science Foundation of Guangdong Province of China (2019A1515011672), and Fundamental Research Funds for the Central Universities (N2017Y05).
Publisher Copyright:
© 2020 Wiley Periodicals LLC
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Mild cognitive impairment affects 36% of people aged 65 years and over in China, and around 50% transition from mild cognitive impairment to dementia within 3 years. Early intervention can slow down disease progression and thus delay dementia onset. The purpose of this article is to outline the protocol of an ongoing randomized controlled trial in mainland China that will evaluate the effects and feasibility of a 6-month multicomponent integrative intervention on the speed of progression of mild cognitive impairment to dementia. Ninety-six community-dwelling older adults, aged 65 years and older, will be recruited (recruitment will be completed in May 2020), using strict inclusion/exclusion criteria, from two community health service centers in Guangzhou, Guangdong province. Participants will be allocated to receive either the multicomponent integrative intervention or usual care. The core components of the intervention are cognitive training, dietary instruction, physical activity, and management of vascular risk factors. Data are collected at the beginning of the study, then at 1, 3, and 6 months. The primary outcome is cognitive function. The main secondary outcomes are exercise capacity, comprehensive physical capacity, depression, and quality of life. An intention-to-treat analysis will be conducted. The study will be completed in 2021. The multicomponent integrative intervention detailed in this protocol could be incorporated into dementia prevention programs in community health service centers, or other similar settings, to delay the onset of dementia.
AB - Mild cognitive impairment affects 36% of people aged 65 years and over in China, and around 50% transition from mild cognitive impairment to dementia within 3 years. Early intervention can slow down disease progression and thus delay dementia onset. The purpose of this article is to outline the protocol of an ongoing randomized controlled trial in mainland China that will evaluate the effects and feasibility of a 6-month multicomponent integrative intervention on the speed of progression of mild cognitive impairment to dementia. Ninety-six community-dwelling older adults, aged 65 years and older, will be recruited (recruitment will be completed in May 2020), using strict inclusion/exclusion criteria, from two community health service centers in Guangzhou, Guangdong province. Participants will be allocated to receive either the multicomponent integrative intervention or usual care. The core components of the intervention are cognitive training, dietary instruction, physical activity, and management of vascular risk factors. Data are collected at the beginning of the study, then at 1, 3, and 6 months. The primary outcome is cognitive function. The main secondary outcomes are exercise capacity, comprehensive physical capacity, depression, and quality of life. An intention-to-treat analysis will be conducted. The study will be completed in 2021. The multicomponent integrative intervention detailed in this protocol could be incorporated into dementia prevention programs in community health service centers, or other similar settings, to delay the onset of dementia.
KW - cognitive function
KW - dementia
KW - quality of life
KW - randomized controlled trial
UR - http://www.scopus.com/inward/record.url?scp=85087440382&partnerID=8YFLogxK
U2 - 10.1002/nur.22050
DO - 10.1002/nur.22050
M3 - Journal article
C2 - 32627231
AN - SCOPUS:85087440382
SN - 0160-6891
VL - 43
SP - 307
EP - 316
JO - Research in Nursing and Health
JF - Research in Nursing and Health
IS - 4
ER -