A mild and efficient palladium-catalyzed cyanation of aryl mesylates in water or tBuOH/water

Pui Yee Yeung, Chau Ming So, Chak Po Lau, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

121 Citations (Scopus)


Cool and compatible: Aryl mesylates and tosylates underwent palladium-catalyzed cyanation under mild, aqueous conditions at 65-80°C (see scheme). In many cases, water could be used as the reaction medium without a cosolvent, and a variety of substituents R, such as keto, aldehyde, ester, free amine, and nitrile groups, remained intact during the transformation. Cy=cyclohexyl, Ms=methanesulfonyl, Ts=p-toluenesulfonyl. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)8918-8922
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number47
Publication statusPublished - 15 Nov 2010


  • cross-coupling
  • cyanation
  • mesylates
  • palladium
  • phosphanes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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