A Method and system for temporal evolutional optogenetics enabled by optical wavefront shaping

Puxiang Lai (Inventor), Lei Sun (Inventor), Tianting Zhong (Inventor), Zhihai Qiu (Inventor)

Research output: Patents, agreements, assignments and companiesPatents granted

Abstract

A method for optogenetics experiments, based on wavefront shaping and including: calculating the transmission matrix between an input end and an output end of the multimode fiber under a fixed shape; implanting the output end into an intracranial space of an experimental subject; and performing wavefront compensation to a light to be input into the input end, according to the spatial position of the optical stimulation and the transmission matrix of the multimode fiber, to form a compensated expanded light, and inputting the compensated expanded light from the input end into the multimode fiber, such that the compensated expanded light, after being transmitted by the multimode fiber to the output end and output from the output end, is capable of focusing at the spatial position of the optical stimulation.
Original languageEnglish
Patent numberUS11,633,620
Filing date8/04/20
Publication statusPublished - 25 Apr 2023

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