A meta-analytic study of the neural systems for auditory processing of lexical tones

V.P.Y. Kwok, G. Dan, K. Yakpo, S. Matthews, P.T. Fox, Ping Li, L.-H. Tan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

16 Citations (Scopus)


© 2017 Kwok, Dan, Yakpo, Matthews, Fox, Li and Tan.The neural systems of lexical tone processing have been studied for many years. However, previous findings have been mixed with regard to the hemispheric specialization for the perception of linguistic pitch patterns in native speakers of tonal language. In this study, we performed two activation likelihood estimation (ALE) meta-analyses, one on neuroimaging studies of auditory processing of lexical tones in tonal languages (17 studies), and the other on auditory processing of lexical information in non-tonal languages as a control analysis for comparison (15 studies). The lexical tone ALE analysis showed significant brain activations in bilateral inferior prefrontal regions, bilateral superior temporal regions and the right caudate, while the control ALE analysis showed significant cortical activity in the left inferior frontal gyrus and left temporoparietal regions. However, we failed to obtain significant differences from the contrast analysis between two auditory conditions, which might be caused by the limited number of studies available for comparison. Although the current study lacks evidence to argue for a lexical tone specific activation pattern, our results provide clues and directions for future investigations on this topic, more sophisticated methods are needed to explore this question in more depth as well.
Original languageEnglish
Article number375
JournalFrontiers in Human Neuroscience
Publication statusPublished - 26 Jul 2017
Externally publishedYes


  • Activation likelihood estimation (ALE) meta-analysis
  • Auditory processing
  • Lexical tones
  • Meta-analysis
  • Neuroimaging

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience


Dive into the research topics of 'A meta-analytic study of the neural systems for auditory processing of lexical tones'. Together they form a unique fingerprint.

Cite this