TY - GEN
T1 - A mechanical model of biological cells in microinjection
AU - Tan, Youhua
AU - Sun, Dong
AU - Huang, Wenhao
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Microinjection is an effective technique to introduce foreign materials into a biological cell. Although great developments have been achieved, a full understanding of the mechanical response of biological cells to injection operation remains deficient. In this paper, a mechanical model based on membrane theory is proposed. This model utilizes the Mooney-Rivlin material to model the deformation of biomembrane. The relationship between the injection force and the deformation of biological cells is established through the quasi-static equilibrium equations, which are solved by the Runge-Kutta numerical method. To verify the mechanical model, experiments are performed on microinjection of zebrafish and medaka embryos. It is demonstrated that the modeling results agree well with the experimental data, which shows that the proposed model can be used to estimate the mechanical properties of cell biomembranes.
AB - Microinjection is an effective technique to introduce foreign materials into a biological cell. Although great developments have been achieved, a full understanding of the mechanical response of biological cells to injection operation remains deficient. In this paper, a mechanical model based on membrane theory is proposed. This model utilizes the Mooney-Rivlin material to model the deformation of biomembrane. The relationship between the injection force and the deformation of biological cells is established through the quasi-static equilibrium equations, which are solved by the Runge-Kutta numerical method. To verify the mechanical model, experiments are performed on microinjection of zebrafish and medaka embryos. It is demonstrated that the modeling results agree well with the experimental data, which shows that the proposed model can be used to estimate the mechanical properties of cell biomembranes.
UR - https://www.scopus.com/pages/publications/70349177240
U2 - 10.1109/ROBIO.2009.4912980
DO - 10.1109/ROBIO.2009.4912980
M3 - Conference article published in proceeding or book
SN - 9781424426799
T3 - 2008 IEEE International Conference on Robotics and Biomimetics, ROBIO 2008
SP - 61
EP - 66
BT - 2008 IEEE International Conference on Robotics and Biomimetics, ROBIO 2008
PB - IEEE Computer Society
T2 - 2008 IEEE International Conference on Robotics and Biomimetics, ROBIO 2008
Y2 - 21 February 2009 through 26 February 2009
ER -