A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Yu Man Ho; Ngan Pan Bennett Au; Ka Leung Wong; Chris Tsz Leung Chan; Wai Ming Kwok; Ga Lai Law; Kwong Kit Tang; Wai Yeung Wong; Chi Him Eddie Ma; Michael Hon Wah Lam

doi:10.1039/c3cc48934e

A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Yu Man Ho
, Ngan Pan Bennett Au
, Ka Leung Wong
, Chris Tsz Leung Chan
, Wai Ming Kwok
, Ga Lai Law
, Kwong Kit Tang
, Wai Yeung Wong
, Chi Him Eddie Ma
, Michael Hon Wah Lam

Research output: Journal article publication › Journal article › Academic research › peer-review

42 Citations (Scopus)

Abstract

Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L1)]2(μ-dppm)}2+(1) and {[Pt(L2)]2(μ-dppm)}2+(2), as lysosome-specific two-photon imaging probes.

Original language	English
Pages (from-to)	4161-4163
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	32
DOIs	https://doi.org/10.1039/c3cc48934e
Publication status	Published - 25 Apr 2014

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc48934e

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title = "A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons",

abstract = "Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, \{[Pt(L1)]2(μ-dppm)\}2+(1) and \{[Pt(L2)]2(μ-dppm)\}2+(2), as lysosome-specific two-photon imaging probes.",

author = "Ho, \{Yu Man\} and Au, \{Ngan Pan Bennett\} and Wong, \{Ka Leung\} and Chan, \{Chris Tsz Leung\} and Kwok, \{Wai Ming\} and Law, \{Ga Lai\} and Tang, \{Kwong Kit\} and Wong, \{Wai Yeung\} and Ma, \{Chi Him Eddie\} and Lam, \{Michael Hon Wah\}",

year = "2014",

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doi = "10.1039/c3cc48934e",

language = "English",

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T1 - A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

AU - Ho, Yu Man

AU - Au, Ngan Pan Bennett

AU - Wong, Ka Leung

AU - Chan, Chris Tsz Leung

AU - Kwok, Wai Ming

AU - Law, Ga Lai

AU - Tang, Kwong Kit

AU - Wong, Wai Yeung

AU - Ma, Chi Him Eddie

AU - Lam, Michael Hon Wah

PY - 2014/4/25

Y1 - 2014/4/25

N2 - Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L1)]2(μ-dppm)}2+(1) and {[Pt(L2)]2(μ-dppm)}2+(2), as lysosome-specific two-photon imaging probes.

AB - Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L1)]2(μ-dppm)}2+(1) and {[Pt(L2)]2(μ-dppm)}2+(2), as lysosome-specific two-photon imaging probes.

UR - https://www.scopus.com/pages/publications/84897008214

U2 - 10.1039/c3cc48934e

DO - 10.1039/c3cc48934e

M3 - Journal article

C2 - 24418895

SN - 1359-7345

VL - 50

SP - 4161

EP - 4163

JO - Chemical Communications

JF - Chemical Communications

IS - 32

ER -

A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Abstract

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