Abstract
As published initially in this same journal in 2000 (1), the lipid extract of Perna canaliculus (New Zealand green-lipped mussel; Lyprinol®) is known for its anti-inflammatory effects in animal models and in human controlled studies (arthritis; asthma). As a follow-up of its effects on pain in a rat model of adjuvant-induced arthritis (AIA) (2), we studied its effects on the production of cytokines known to be associated with inflammation (IL-6, IL-lα. TNF-α, IFN-γ). Feeding with Lyprinol was associated with significantly decreased expression levels of TNF-α and IFN-γ when compared to Naproxen (positive control) and, even more when compared with sham and extra-virgin olive oil (negative control). When compared to Naproxen, sham and extra-virgin olive oil, the levels of IL-6 and IL-lα. were also marginally decreased in rats fed with Lyprinol. This study demonstrates that AIA rats fed with Lyprinol had decreased production of cytokines associated with inflammation.
Original language | English |
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Pages (from-to) | 148-153 |
Number of pages | 6 |
Journal | European Annals of Allergy and Clinical Immunology |
Volume | 40 |
Issue number | 4 |
Publication status | Published - 1 Dec 2008 |
Keywords
- Adjuvantinduced arthritis
- Lyprinol®
- NSAID
- Pro-inflammatory cytokines
ASJC Scopus subject areas
- Immunology and Allergy