A high resolution digital ultrasound system for imaging of zebrafish

Lei Sun, Suvimol Sangkatumvong, K. Kirk Shung

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

6 Citations (Scopus)


The zebrafish (Danio rerio) has become a popular animal model for the study of vertebrate biology, due to its simple anatomy, rapid external development, and easiness to maintain in large numbers. However, traditional imaging modalities do not provide adequate spatial resolutions to describe its very small internal structures. In this research, an ultrasound bio-microscope (UBM) system (exceeding 80MHz) was developed with resolutions around 20 micron for in vivo imaging of the zebrafish. This UBM system was implemented in a fully digital version with the capability of B-mode imaging as well as pulsed-wave spectral Doppler measurement. The system has -6dB resolutions of 19 and 28 microns axially and laterally, respectively, by phantom measurement. In vivo experiments on zebrafish displayed its detailed internal structures. Preliminary spectral Doppler measurement on flow phantom showed that this instrument permits flow measurement up to 40 cm/s, with velocity and temporal resolutions of 150 micron/s and 100 ms, respectively, in a sample volume with dimensions of 40 and 150 microns laterally and axially.
Original languageEnglish
Title of host publication2006 IEEE International Ultrasonics Symposium, IUS
Number of pages4
Publication statusPublished - 1 Dec 2006
Externally publishedYes

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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