A high-frame rate high-frequency ultrasonic system for cardiac imaging in mice

Lei Sun, William D. Richard, Jonathan M. Cannata, Ching C. Feng, Jeffrey A. Johnson, Jesse T. Yen, K. Kirk Shung

Research output: Journal article publicationJournal articleAcademic researchpeer-review

43 Citations (Scopus)

Abstract

We report the development of a high-frequency (30-50 MHz), real-time ultrasonic Imaging system for cardiac imaging in mice. This system is capable of producing images at 130 frames per second (fps) with a spatial resolution of less than 50 μm. A novel mechanical sector probe was developed that utilizes a magnetic drive mechanism and custom-built servo controller for high speed and accuracy. Additionally, a very light-weight (< 0.28 g), single-element transducer was constructed and used to reduce the mass load on the motor. The Imaging electronics were triggered according to the angular position of the transducer in order to compensate for the varying speed of the sector motor. This strategy ensured the production of equally spaced scan lines with minimal jitter. Wire phantom testing showed that the system axial and lateral resolutions were 48 μm and 72 μm, respectively. In vivo experiments showed that high-frequency ultrasonic Imaging at 130 fps is capable of showing a detailed depiction of a beating mouse heart.
Original languageEnglish
Pages (from-to)1648-1654
Number of pages7
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume54
Issue number8
DOIs
Publication statusPublished - 1 Aug 2007
Externally publishedYes

ASJC Scopus subject areas

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering

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