A General Suzuki-Miyaura Coupling of Aryl Chlorides with Potassium Aryltrifluoroborates in Water Catalyzed by an Efficient CPCy Phendole-phos-Palladium Complex

On Ying Yuen, Shun Man Wong, Kin Fai Chan, Chau Ming So, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

7 Citations (Scopus)

Abstract

General examples of the palladium-catalyzed Suzuki-Miyaura cross-coupling of aryl or heteroaryl chlorides with potassium aryl- or heteroaryltrifluoroborates in water are presented. The palladium complex comprising of palladium(II) acetate and 'CPCy Phendole-phos' is found to be a highly effective catalyst system for this coupling reaction with low catalyst loading (down to 0.005 mol% Pd).
Original languageEnglish
Article numberss-2014-h0287-op
Pages (from-to)2826-2832
Number of pages7
JournalSynthesis (Germany)
Volume46
Issue number20
DOIs
Publication statusPublished - 16 Oct 2014

Keywords

  • aryl chloride
  • arylation
  • palladium
  • potassium aryltrifluoroborates
  • Suzuki-Miyaura reaction
  • water

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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