A general direct arylation of polyfluoroarenes with heteroaryl and aryl chlorides catalyzed by palladium indolylphosphine complexes

On Ying Yuen, Mueangkaew Charoensak, Chau Ming So, Chutima Kuhakarn, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

16 Citations (Scopus)


KGaA, Weinheim. The first general examples of direct coupling of heteroaryl chlorides, especially substituted 2-pyridyl chlorides which were previously found to be problematic, with electron-deficient polyfluoroarenes are reported. Pd(OAc)2 associated with 3-(dicyclohexylphosphino)-2-phenylindole L1 serves as the effective catalyst which allows the challenging direct coupling of heteroaryl chlorides and polyfluoroarenes. In addition to heterocycles, a wide range of non-activated and activated aryl chlorides and alkenyl chlorides were also applicable under this catalyst system. A catalyst loading down to 1 mol% Pd can be achieved.
Original languageEnglish
Pages (from-to)857-861
Number of pages5
JournalChemistry - An Asian Journal
Issue number4
Publication statusPublished - 1 Jan 2015


  • aryl chlorides
  • C£H arylation
  • palladium
  • phosphine
  • polyfluoroarenes

ASJC Scopus subject areas

  • Chemistry(all)

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