A gel-forming clusteroluminogenic polymer with tunable emission behavior as a sustained-release carrier enabling real-time tracking during bioactive agent delivery

Wing Fu Lai (Corresponding Author), Eric M. Huang, Wing Tak Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)

Abstract

Sustained-release carriers with intrinsic luminescence exhibit the potential to combine imaging with bioactive agent delivery in practice. This study reports the synthesis and properties of CT, which is a gel-forming and highly tunable non-conjugated polymer with intrinsic luminescence. Owing to the excitation wavelength-dependent emission tunability of CT, optical imaging can be performed in a wide range of excitation wavelengths. This study is the first proof-of-concept study successfully integrating the property of clusterization-triggered emission into carrier design for combining imaging with bioactive agent delivery. By using cancer therapy as a practical example, our results demonstrate that CT is a depot system that cannot only enhance in vivo antitumor efficacy but can also allow its location and gelation process to be tracked in real time by giving an intrinsic blue-colored fluorescence signal. Together with its high biocompatibility, CT shows high practical potential for executing self-illuminating therapy to tackle cancer.

Original languageEnglish
Article number100876
JournalApplied Materials Today
Volume21
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Excitation wavelength-dependent emission
  • Gelation
  • Imaging
  • Luminescence
  • Sustained release

ASJC Scopus subject areas

  • Materials Science(all)

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