A facile metal-phenolic-amine strategy for dual-functionalization of blood-contacting devices with antibacterial and anticoagulant properties

Qiufen Tu, Xuehong Shen, Yaowen Liu, Qiang Zhang, Xin Zhao, Manfred F. Maitz, Tao Liu, Hua Qiu, Jin Wang, Nan Huang, Zhilu Yang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

30 Citations (Scopus)


Thrombosis and infections of extracorporeal circuits and indwelling medical devices are the two major life-threatening complications faced in clinical practice. Herein, we report a novel and facile metal-phenolic-amine surface modification strategy to engineer a multifunctional coating on these devices to combat thrombosis and infection. This strategy is inspired by the metal-catecholamine coordination complex of [Fe(dopa) 3 ] in mussels, in which Cu(ii) ions (metal), plant polyphenol gallic acid (phenol) and cystamine (amine) are employed to fabricate a copper-phenolic-amine network. Our in vitro and in vivo experiments reveal that the resultant Cu(ii)-chelating coatings endow the modified tubing with not only durable antibacterial properties, but also capability to persistently generate anticoagulant therapeutic nitric oxide (NO) gas in the presence of endogenous S-nitrosothiols (RSNO) from fresh blood. We anticipate that our simple and multifunctional coating strategy will be a milestone in the development of surface engineering, especially that of biomedical devices.

Original languageEnglish
Pages (from-to)265-275
Number of pages11
JournalMaterials Chemistry Frontiers
Issue number2
Publication statusPublished - 1 Feb 2019

ASJC Scopus subject areas

  • Materials Chemistry
  • Materials Science(all)

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