Abstract
Thrombosis and infections of extracorporeal circuits and indwelling medical devices are the two major life-threatening complications faced in clinical practice. Herein, we report a novel and facile metal-phenolic-amine surface modification strategy to engineer a multifunctional coating on these devices to combat thrombosis and infection. This strategy is inspired by the metal-catecholamine coordination complex of [Fe(dopa) 3 ] in mussels, in which Cu(ii) ions (metal), plant polyphenol gallic acid (phenol) and cystamine (amine) are employed to fabricate a copper-phenolic-amine network. Our in vitro and in vivo experiments reveal that the resultant Cu(ii)-chelating coatings endow the modified tubing with not only durable antibacterial properties, but also capability to persistently generate anticoagulant therapeutic nitric oxide (NO) gas in the presence of endogenous S-nitrosothiols (RSNO) from fresh blood. We anticipate that our simple and multifunctional coating strategy will be a milestone in the development of surface engineering, especially that of biomedical devices.
Original language | English |
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Pages (from-to) | 265-275 |
Number of pages | 11 |
Journal | Materials Chemistry Frontiers |
Volume | 3 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 2019 |
ASJC Scopus subject areas
- Materials Chemistry
- General Materials Science