A double-blind, placebo-controlled, randomised trial of active manuka honey and standard oral care for radiation-induced oral mucositis

Joy Bardy, Alexandros Molasiotis, W. David Ryder, Kathleen Mais, Andrew Sykes, Beng Yap, Lip Lee, Ed Kaczmarski, Nicholas Slevin

Research output: Journal article publicationJournal articleAcademic researchpeer-review

60 Citations (Scopus)

Abstract

Our aim was to investigate the effect of active manuka honey on radiation-induced mucositis. A total of 131 patients diagnosed with head and neck cancer who were having radiotherapy to the oral cavity or oropharyngeal area were recruited into the study, and were randomly allocated to take either manuka honey or placebo (golden syrup) 20 ml 4 times daily for 6 weeks. Mucositis was assessed according to the Radiation Therapy Oncology Group (RTOG) scale at baseline, weekly during radiotherapy, and twice weekly thereafter until the mucositis resolved. The patient's weight was recorded at the same time as the mucositis was assessed. Throat swabs to identify bacterial or fungal infections were taken at baseline, and during and after radiotherapy. There was no significant difference between honey and golden syrup in their effects on mucositis. Active manuka honey did not improve mucositis, but both the honey and the syrup seemed to be associated with a reduction in bacterial infections. Compliance was a problem after the onset of mucositis, which may have affected the findings.
Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume50
Issue number3
DOIs
Publication statusPublished - 1 Apr 2012
Externally publishedYes

Keywords

  • Head and neck cancer
  • Honey
  • Mucositis
  • Radiotherapy
  • Randomised controlled trial

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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