A comparative study of simulated electric fields of transcranial magnetic stimulation targeting different cortical motor regions

Jiaqi Zhang; Bingbing Zhang; Zhongfei Bai; Kenneth N. K. Fong

doi:10.1002/bem.22523

A comparative study of simulated electric fields of transcranial magnetic stimulation targeting different cortical motor regions

Jiaqi Zhang (Corresponding Author), Bingbing Zhang, Zhongfei Bai (Corresponding Author), Kenneth N. K. Fong

Research output: Journal article publication › Journal article › Academic research › peer-review

Abstract

This computational simulation study investigates the strength of transcranial magnetic stimulation (TMS)-induced electric fields (EF) in primary motor cortex (M1) and secondary motor areas. Our results reveal high interindividual variability in the strength of TMS-induced EF responses in secondary motor areas, relative to the stimulation threshold in M1. Notably, the activation of the supplementary motor area requires high-intensity stimulation, which could be attributed to the greater scalp-to-cortex distance observed over this area. These findings emphasize the importance of individualized planning using computational simulation for optimizing neuromodulation strategies targeting the cortical motor system.

Original language	English
Journal	Bioelectromagnetics
DOIs	https://doi.org/10.1002/bem.22523
Publication status	Published - 16 Sept 2024

Keywords

electric fields
motor cortex
simulation
transcranial magnetic stimulation

ASJC Scopus subject areas

Biophysics
Physiology
Radiology Nuclear Medicine and imaging

More information

10.1002/bem.22523

Cite this

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title = "A comparative study of simulated electric fields of transcranial magnetic stimulation targeting different cortical motor regions",

abstract = "This computational simulation study investigates the strength of transcranial magnetic stimulation (TMS)-induced electric fields (EF) in primary motor cortex (M1) and secondary motor areas. Our results reveal high interindividual variability in the strength of TMS-induced EF responses in secondary motor areas, relative to the stimulation threshold in M1. Notably, the activation of the supplementary motor area requires high-intensity stimulation, which could be attributed to the greater scalp-to-cortex distance observed over this area. These findings emphasize the importance of individualized planning using computational simulation for optimizing neuromodulation strategies targeting the cortical motor system.",

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author = "Jiaqi Zhang and Bingbing Zhang and Zhongfei Bai and Fong, {Kenneth N. K.}",

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AU - Zhang, Jiaqi

AU - Zhang, Bingbing

AU - Bai, Zhongfei

AU - Fong, Kenneth N. K.

PY - 2024/9/16

Y1 - 2024/9/16

N2 - This computational simulation study investigates the strength of transcranial magnetic stimulation (TMS)-induced electric fields (EF) in primary motor cortex (M1) and secondary motor areas. Our results reveal high interindividual variability in the strength of TMS-induced EF responses in secondary motor areas, relative to the stimulation threshold in M1. Notably, the activation of the supplementary motor area requires high-intensity stimulation, which could be attributed to the greater scalp-to-cortex distance observed over this area. These findings emphasize the importance of individualized planning using computational simulation for optimizing neuromodulation strategies targeting the cortical motor system.

AB - This computational simulation study investigates the strength of transcranial magnetic stimulation (TMS)-induced electric fields (EF) in primary motor cortex (M1) and secondary motor areas. Our results reveal high interindividual variability in the strength of TMS-induced EF responses in secondary motor areas, relative to the stimulation threshold in M1. Notably, the activation of the supplementary motor area requires high-intensity stimulation, which could be attributed to the greater scalp-to-cortex distance observed over this area. These findings emphasize the importance of individualized planning using computational simulation for optimizing neuromodulation strategies targeting the cortical motor system.

KW - electric fields

KW - motor cortex

KW - simulation

KW - transcranial magnetic stimulation

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DO - 10.1002/bem.22523

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SN - 0197-8462

JO - Bioelectromagnetics

JF - Bioelectromagnetics

ER -

A comparative study of simulated electric fields of transcranial magnetic stimulation targeting different cortical motor regions

Abstract

Keywords

ASJC Scopus subject areas

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