A Comparative Study of Drug Distribution Using Photoacoustic Imaging and Radionuclide-Based Sampling in PEGylated Gold Nanostars-Mediated Photothermal Therapy

Chao Cheng Chen; Ju Yu Chen; Hui Wen Chan; Deng Yuan Chang; Hsin Ell Wang; Liang Ting Lin

doi:10.1007/978-3-030-92786-8_3

A Comparative Study of Drug Distribution Using Photoacoustic Imaging and Radionuclide-Based Sampling in PEGylated Gold Nanostars-Mediated Photothermal Therapy

Chao Cheng Chen
, Ju Yu Chen
, Hui Wen Chan
, Deng Yuan Chang
, Hsin Ell Wang
, Liang Ting Lin

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

Abstract

Gold nanoparticles attract great attention in potential theranostics options for aggressive triple-negative breast cancer (TNBC), by sensitizing tumor to non-invasive photothermal therapy (PTT) and enabling multifunctional imaging, with an enhanced efficacy and reduced systemic cytotoxicity. Gold nanostars possess tremendous benefits among gold nanostructures, due to the distinct absorption peak in near-infrared region and excellent photothermal conversion efficiency. The surface plasmon resonance of nanostars enables photoacoustic imaging (PAI) by an efficient conversion of photons to photoacoustic signals. In this study, we investigated the PEGylated gold nanostars (pAuNSs) uptake in orthotopic TNBC tumor with PAI and radionuclide-based biodistribution. A prominent pAuNSs uptake in tumor was found steadily within 2-24 h after intravenous injection by both methods. The tumor was exposed to laser (808 nm, 1 W/cm²) for 3 min twice at 24 h post-intravenous injection. The photothermal effect of pAuNSs induced a rise in tumor temperature to 55 ℃, which could kill tumor tissue by thermal ablation. The tumor in pAuNSs-mediated laser group was markedly shrunken up to day 21 post-treatment, also reflected by the reduction of luciferase activity in bioluminescent imaging. Overall, this work presented a novel nanoplatform for PAI-guided PTT mediated by pAuNSs and revealed effective thermal ablation in eliminating TNBC tumor.

Original language	English
Title of host publication	Future Trends and Challenges of Molecular Imaging and AI Innovation - Proceedings of FASMI 2020
Editors	Kang-Ping Lin, Ren-Shyan Liu, Bang-Hung Yang
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	17-25
Number of pages	9
ISBN (Print)	9783030927851
DOIs	https://doi.org/10.1007/978-3-030-92786-8_3
Publication status	Published - 2022
Event	International conference of Federation of Asian Societies for Molecular Imaging, FASMI 2020 - Taipei, Taiwan Duration: 20 Nov 2020 → 22 Nov 2020

Publication series

Name	Springer Proceedings in Physics
Volume	272
ISSN (Print)	0930-8989
ISSN (Electronic)	1867-4941

Conference

Conference	International conference of Federation of Asian Societies for Molecular Imaging, FASMI 2020
Country/Territory	Taiwan
City	Taipei
Period	20/11/20 → 22/11/20

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biodistribution
Gold nanoparticles
Photoacoustic imaging
Photothermal therapy
Triple-negative breast cancer

ASJC Scopus subject areas

General Physics and Astronomy

More information

10.1007/978-3-030-92786-8_3

Cite this

Chen, C. C., Chen, J. Y., Chan, H. W., Chang, D. Y., Wang, H. E., & Lin, L. T. (2022). A Comparative Study of Drug Distribution Using Photoacoustic Imaging and Radionuclide-Based Sampling in PEGylated Gold Nanostars-Mediated Photothermal Therapy. In K.-P. Lin, R.-S. Liu, & B.-H. Yang (Eds.), Future Trends and Challenges of Molecular Imaging and AI Innovation - Proceedings of FASMI 2020 (pp. 17-25). (Springer Proceedings in Physics; Vol. 272). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-92786-8_3

Chen, Chao Cheng ; Chen, Ju Yu ; Chan, Hui Wen et al. / A Comparative Study of Drug Distribution Using Photoacoustic Imaging and Radionuclide-Based Sampling in PEGylated Gold Nanostars-Mediated Photothermal Therapy. Future Trends and Challenges of Molecular Imaging and AI Innovation - Proceedings of FASMI 2020. editor / Kang-Ping Lin ; Ren-Shyan Liu ; Bang-Hung Yang. Springer Science and Business Media Deutschland GmbH, 2022. pp. 17-25 (Springer Proceedings in Physics).

@inproceedings{dd753f2859ae4e7e96210e571ba220dd,

title = "A Comparative Study of Drug Distribution Using Photoacoustic Imaging and Radionuclide-Based Sampling in PEGylated Gold Nanostars-Mediated Photothermal Therapy",

abstract = "Gold nanoparticles attract great attention in potential theranostics options for aggressive triple-negative breast cancer (TNBC), by sensitizing tumor to non-invasive photothermal therapy (PTT) and enabling multifunctional imaging, with an enhanced efficacy and reduced systemic cytotoxicity. Gold nanostars possess tremendous benefits among gold nanostructures, due to the distinct absorption peak in near-infrared region and excellent photothermal conversion efficiency. The surface plasmon resonance of nanostars enables photoacoustic imaging (PAI) by an efficient conversion of photons to photoacoustic signals. In this study, we investigated the PEGylated gold nanostars (pAuNSs) uptake in orthotopic TNBC tumor with PAI and radionuclide-based biodistribution. A prominent pAuNSs uptake in tumor was found steadily within 2-24 h after intravenous injection by both methods. The tumor was exposed to laser (808 nm, 1 W/cm2) for 3 min twice at 24 h post-intravenous injection. The photothermal effect of pAuNSs induced a rise in tumor temperature to 55 ℃, which could kill tumor tissue by thermal ablation. The tumor in pAuNSs-mediated laser group was markedly shrunken up to day 21 post-treatment, also reflected by the reduction of luciferase activity in bioluminescent imaging. Overall, this work presented a novel nanoplatform for PAI-guided PTT mediated by pAuNSs and revealed effective thermal ablation in eliminating TNBC tumor.",

keywords = "Biodistribution, Gold nanoparticles, Photoacoustic imaging, Photothermal therapy, Triple-negative breast cancer",

author = "Chen, \{Chao Cheng\} and Chen, \{Ju Yu\} and Chan, \{Hui Wen\} and Chang, \{Deng Yuan\} and Wang, \{Hsin Ell\} and Lin, \{Liang Ting\}",

note = "Funding Information: Acknowledgements This work is supported by Early Career Scheme (25103719) by the Research Grant Council, HKSAR. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.; International conference of Federation of Asian Societies for Molecular Imaging, FASMI 2020 ; Conference date: 20-11-2020 Through 22-11-2020",

year = "2022",

doi = "10.1007/978-3-030-92786-8\_3",

language = "English",

isbn = "9783030927851",

series = "Springer Proceedings in Physics",

publisher = "Springer Science and Business Media Deutschland GmbH",

pages = "17--25",

editor = "Kang-Ping Lin and Ren-Shyan Liu and Bang-Hung Yang",

booktitle = "Future Trends and Challenges of Molecular Imaging and AI Innovation - Proceedings of FASMI 2020",

address = "Germany",

}

Chen, CC, Chen, JY, Chan, HW, Chang, DY, Wang, HE & Lin, LT 2022, A Comparative Study of Drug Distribution Using Photoacoustic Imaging and Radionuclide-Based Sampling in PEGylated Gold Nanostars-Mediated Photothermal Therapy. in K-P Lin, R-S Liu & B-H Yang (eds), Future Trends and Challenges of Molecular Imaging and AI Innovation - Proceedings of FASMI 2020. Springer Proceedings in Physics, vol. 272, Springer Science and Business Media Deutschland GmbH, pp. 17-25, International conference of Federation of Asian Societies for Molecular Imaging, FASMI 2020, Taipei, Taiwan, 20/11/20. https://doi.org/10.1007/978-3-030-92786-8_3

A Comparative Study of Drug Distribution Using Photoacoustic Imaging and Radionuclide-Based Sampling in PEGylated Gold Nanostars-Mediated Photothermal Therapy. / Chen, Chao Cheng; Chen, Ju Yu; Chan, Hui Wen et al.
Future Trends and Challenges of Molecular Imaging and AI Innovation - Proceedings of FASMI 2020. ed. / Kang-Ping Lin; Ren-Shyan Liu; Bang-Hung Yang. Springer Science and Business Media Deutschland GmbH, 2022. p. 17-25 (Springer Proceedings in Physics; Vol. 272).

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

TY - GEN

T1 - A Comparative Study of Drug Distribution Using Photoacoustic Imaging and Radionuclide-Based Sampling in PEGylated Gold Nanostars-Mediated Photothermal Therapy

AU - Chen, Chao Cheng

AU - Chen, Ju Yu

AU - Chan, Hui Wen

AU - Chang, Deng Yuan

AU - Wang, Hsin Ell

AU - Lin, Liang Ting

N1 - Funding Information: Acknowledgements This work is supported by Early Career Scheme (25103719) by the Research Grant Council, HKSAR. Publisher Copyright: © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

PY - 2022

Y1 - 2022

N2 - Gold nanoparticles attract great attention in potential theranostics options for aggressive triple-negative breast cancer (TNBC), by sensitizing tumor to non-invasive photothermal therapy (PTT) and enabling multifunctional imaging, with an enhanced efficacy and reduced systemic cytotoxicity. Gold nanostars possess tremendous benefits among gold nanostructures, due to the distinct absorption peak in near-infrared region and excellent photothermal conversion efficiency. The surface plasmon resonance of nanostars enables photoacoustic imaging (PAI) by an efficient conversion of photons to photoacoustic signals. In this study, we investigated the PEGylated gold nanostars (pAuNSs) uptake in orthotopic TNBC tumor with PAI and radionuclide-based biodistribution. A prominent pAuNSs uptake in tumor was found steadily within 2-24 h after intravenous injection by both methods. The tumor was exposed to laser (808 nm, 1 W/cm2) for 3 min twice at 24 h post-intravenous injection. The photothermal effect of pAuNSs induced a rise in tumor temperature to 55 ℃, which could kill tumor tissue by thermal ablation. The tumor in pAuNSs-mediated laser group was markedly shrunken up to day 21 post-treatment, also reflected by the reduction of luciferase activity in bioluminescent imaging. Overall, this work presented a novel nanoplatform for PAI-guided PTT mediated by pAuNSs and revealed effective thermal ablation in eliminating TNBC tumor.

AB - Gold nanoparticles attract great attention in potential theranostics options for aggressive triple-negative breast cancer (TNBC), by sensitizing tumor to non-invasive photothermal therapy (PTT) and enabling multifunctional imaging, with an enhanced efficacy and reduced systemic cytotoxicity. Gold nanostars possess tremendous benefits among gold nanostructures, due to the distinct absorption peak in near-infrared region and excellent photothermal conversion efficiency. The surface plasmon resonance of nanostars enables photoacoustic imaging (PAI) by an efficient conversion of photons to photoacoustic signals. In this study, we investigated the PEGylated gold nanostars (pAuNSs) uptake in orthotopic TNBC tumor with PAI and radionuclide-based biodistribution. A prominent pAuNSs uptake in tumor was found steadily within 2-24 h after intravenous injection by both methods. The tumor was exposed to laser (808 nm, 1 W/cm2) for 3 min twice at 24 h post-intravenous injection. The photothermal effect of pAuNSs induced a rise in tumor temperature to 55 ℃, which could kill tumor tissue by thermal ablation. The tumor in pAuNSs-mediated laser group was markedly shrunken up to day 21 post-treatment, also reflected by the reduction of luciferase activity in bioluminescent imaging. Overall, this work presented a novel nanoplatform for PAI-guided PTT mediated by pAuNSs and revealed effective thermal ablation in eliminating TNBC tumor.

KW - Biodistribution

KW - Gold nanoparticles

KW - Photoacoustic imaging

KW - Photothermal therapy

KW - Triple-negative breast cancer

UR - https://www.scopus.com/pages/publications/85126245817

U2 - 10.1007/978-3-030-92786-8_3

DO - 10.1007/978-3-030-92786-8_3

M3 - Conference article published in proceeding or book

AN - SCOPUS:85126245817

SN - 9783030927851

T3 - Springer Proceedings in Physics

SP - 17

EP - 25

BT - Future Trends and Challenges of Molecular Imaging and AI Innovation - Proceedings of FASMI 2020

A2 - Lin, Kang-Ping

A2 - Liu, Ren-Shyan

A2 - Yang, Bang-Hung

PB - Springer Science and Business Media Deutschland GmbH

T2 - International conference of Federation of Asian Societies for Molecular Imaging, FASMI 2020

Y2 - 20 November 2020 through 22 November 2020

ER -

Chen CC, Chen JY, Chan HW, Chang DY, Wang HE, Lin LT. A Comparative Study of Drug Distribution Using Photoacoustic Imaging and Radionuclide-Based Sampling in PEGylated Gold Nanostars-Mediated Photothermal Therapy. In Lin KP, Liu RS, Yang BH, editors, Future Trends and Challenges of Molecular Imaging and AI Innovation - Proceedings of FASMI 2020. Springer Science and Business Media Deutschland GmbH. 2022. p. 17-25. (Springer Proceedings in Physics). doi: 10.1007/978-3-030-92786-8_3

A Comparative Study of Drug Distribution Using Photoacoustic Imaging and Radionuclide-Based Sampling in PEGylated Gold Nanostars-Mediated Photothermal Therapy

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

More information

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